P物质和血管活性肠肽对乙酰胆碱释放的钙依赖性刺激作用。

Calcium-dependent stimulation of acetylcholine release by substance P and vasoactive intestinal polypeptide.

作者信息

Yau W M, Dorsett J A, Youther M L

出版信息

Eur J Pharmacol. 1986 Jan 21;120(2):241-3. doi: 10.1016/0014-2999(86)90547-9.

PMID:2419150

Abstract

In the guinea-pig myenteric plexus-longitudinal muscle preparation from the small intestine, the release of acetylcholine evoked by substance P and vasoactive intestinal polypeptide was examined in vitro. Both neuropeptides stimulated efflux of [3H]acetylcholine from myenteric neurons in a calcium-dependent manner. This observation is consistent with the view that neurotransmitter release elicited by neuropeptides requires the presence of extracellular calcium ions.

摘要

在豚鼠小肠的肌间神经丛 - 纵行肌制备物中，体外研究了P物质和血管活性肠肽诱发的乙酰胆碱释放。两种神经肽均以钙依赖的方式刺激[3H]乙酰胆碱从肌间神经元流出。这一观察结果与神经肽引发的神经递质释放需要细胞外钙离子存在的观点一致。