青少年队列研究中血管紧张素转化酶 2 基因与血压的关系。
The association between the Angiotensin-Converting Enzyme-2 gene and blood pressure in a cohort study of adolescents.
机构信息
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, QC, Canada.
出版信息
BMC Med Genet. 2013 Nov 5;14:117. doi: 10.1186/1471-2350-14-117.
BACKGROUND
The Angiotensin-Converting Enzyme-2 (ACE2) gene, located on chromosome X, is believed to be implicated in blood pressure regulation. However the few studies that have examined this association have yielded mixed results. The objective of this study was to assess the association between tag single nucleotide polymorphisms (SNPs) in the angiotensin-converting enzyme-2 gene with blood pressure and blood pressure change in adolescents.
METHODS
Participants in the Nicotine Dependence in Teens (NDIT) cohort study with blood or saliva samples and at least 3 blood pressure measurements over 5 years were included in the analytic sample (n = 555). Linear growth curve models stratified on sex and ethnicity were used to assess the association between four tag SNPs in the ACE2 gene and systolic (SBP) and diastolic blood pressure (DBP), and blood pressure change.
RESULTS
In males of European descent, rs2074192 and rs233575 were significantly associated with SBP and DBP, and rs2158083 was associated with SBP. In French Canadian males, rs233575 and rs2158083 were significantly associated with DBP. Among females of European descent, rs2074192, rs233575, and rs2158083 were significantly associated with change in SBP over 5 years.
CONCLUSIONS
This is the first study to assess the association between the ACE2 gene with blood pressure and blood pressure change in a cohort of adolescents. Results indicate that several ACE2 gene SNPs are associated with blood pressure or blood pressure change in persons of European descent. However the therapeutic potential of these SNPs should be explored.
背景
血管紧张素转换酶 2（ACE2）基因位于 X 染色体上，被认为与血压调节有关。然而，少数研究该相关性的研究结果喜忧参半。本研究旨在评估血管紧张素转换酶-2 基因中的标签单核苷酸多态性（SNP）与青少年血压和血压变化的相关性。
方法
在尼古丁依赖青少年（NDIT）队列研究中，纳入有血液或唾液样本且在 5 年内至少有 3 次血压测量的参与者作为分析样本（n=555）。使用线性生长曲线模型，按性别和种族分层，评估 ACE2 基因中的四个标签 SNP 与收缩压（SBP）和舒张压（DBP）以及血压变化的关系。
结果
在欧洲裔男性中，rs2074192 和 rs233575 与 SBP 和 DBP 显著相关，rs2158083 与 SBP 相关。在法裔加拿大男性中，rs233575 和 rs2158083 与 DBP 显著相关。在欧洲裔女性中，rs2074192、rs233575 和 rs2158083 与 5 年内 SBP 的变化显著相关。
结论
这是第一项评估 ACE2 基因与青少年队列血压和血压变化相关性的研究。结果表明，几个 ACE2 基因 SNP 与欧洲裔人群的血压或血压变化有关。然而，这些 SNP 的治疗潜力应该进一步探讨。
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