Lio Domenico, Scola Letizia, Giarratana Rosa Maria, Candore Giuseppina, Colonna-Romano Giuseppina, Caruso Calogero, Balistreri Carmela Rita
Immunosenescence Study Group, Department of Biomedicine, Neuroscience and Advanced, Diagnostics (Bi.N.D.), University of Palermo, Palermo, Italy.
Immunosenescence Study Group, Department of Biomedicine, Neuroscience and Advanced, Diagnostics (Bi.N.D.), University of Palermo, Palermo, Italy; Cellular/Molecular Biology and Clinical Pathology Laboratory, Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Palermo, Italy.
Ageing Res Rev. 2021 May;67:101299. doi: 10.1016/j.arr.2021.101299. Epub 2021 Feb 16.
Like other infectious diseases, COVID-19 shows a clinical outcome enormously variable, ranging from asymptomatic to lethal. In Italy, like in other countries, old male individuals, with one or more comorbidity, are the most susceptible group, and show, consequently, the highest mortality, and morbidity, including lethal respiratory distress syndrome, as the most common complication. In addition, another extraordinary peculiarity, that is a surprising resistance to COVID-19, characterizes some Italian nonagenarians/centenarians. Despite having the typical COVID-19 signs and/or symptoms, such exceptional individuals show a surprising tendency to recover from illness and complications. On the other hand, long-lived people have an optimal performance of immune system related to an overexpression of anti-inflammatory variants in immune/inflammatory genes, as demonstrated by our and other groups. Consequently, we suggest long-lived people as an optimal model for detecting genetic profiles associated with the susceptibility and/or protection to COVID-19, to utilize as potential pharmacological targets for preventing or reducing viral infection in more vulnerable individuals.
与其他传染病一样，新冠病毒肺炎（COVID-19）的临床结果差异极大，从无症状到致命不等。在意大利，与其他国家一样，患有一种或多种合并症的老年男性是最易感人群，因此死亡率和发病率最高，其中致命性呼吸窘迫综合征是最常见的并发症。此外，一些意大利的九旬/百岁老人表现出另一个非同寻常的特点，即对新冠病毒肺炎具有惊人的抵抗力。尽管有典型的新冠病毒肺炎体征和/或症状，但这些特殊个体却表现出从疾病和并发症中惊人的康复趋势。另一方面，正如我们和其他团队所证明的，长寿者免疫系统功能最佳，这与免疫/炎症基因中抗炎变体的过度表达有关。因此，我们建议将长寿者作为检测与新冠病毒肺炎易感性和/或抵抗力相关基因谱的最佳模型，以作为预防或减少更脆弱个体病毒感染的潜在药理学靶点。
