ABCB6、ABCB1 和 ABCG1 基因多态性与中国抑郁患者 SSRIs 的抗抑郁反应。
ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients.
机构信息
Bio-X Institutes, Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
出版信息
Pharmacogenomics. 2013 Nov;14(14):1723-30. doi: 10.2217/pgs.13.151.
AIM
Major depressive disorder is a common psychiatric disorder with worldwide prevalence. The most widely prescribed antidepressants are selective serotonin reuptake inhibitors (SSRIs). ATP-binding cassette proteins are responsible for the membrane transport of various molecules including antidepressive drugs. We investigated whether SNPs in ABCB6, ABCB1 and ABCG1 were associated with the treatment response of SSRIs.
MATERIALS & METHODS: A pharmacogenetic study genotyping nine SNPs was conducted in 290 major depressive disorder patients in the Chinese Han population. Allele and genotype frequencies were compared between responders and nonresponders.
RESULTS
The allele frequencies of rs28401781 and rs4148739 in ABCB1 showed significant difference between responders and nonresponders before correction (p = 0.0297 and p = 0.0359, respectively). No significant associations were detected for the ABCB6 or ABCG1 gene.
CONCLUSION
Our results suggest that ABCB1 polymorphisms might be associated with SSRIs treatment response in the Chinese Han population.
目的
重度抑郁症是一种常见的精神疾病，具有世界范围内的流行率。最广泛应用的抗抑郁药是选择性 5-羟色胺再摄取抑制剂（SSRIs）。ATP 结合盒蛋白负责包括抗抑郁药在内的各种分子的膜转运。我们研究了 ABCB6、ABCB1 和 ABCG1 中的 SNPs 是否与 SSRIs 的治疗反应相关。
材料与方法
在汉族的 290 名重度抑郁症患者中进行了一项药物遗传学研究，对 9 个 SNPs 进行基因分型。比较了应答者和无应答者之间的等位基因和基因型频率。
结果
ABCB1 中的 rs28401781 和 rs4148739 等位基因频率在未经校正时在应答者和无应答者之间存在显著差异（分别为 p = 0.0297 和 p = 0.0359）。ABCB6 或 ABCG1 基因未检测到显著相关性。
结论
我们的结果表明，ABCB1 多态性可能与汉族人群中 SSRIs 的治疗反应相关。
Zotero 插件