Hervey-Jumper Shawn L, Singla Nirmish, Gebarski Stephen S, Robertson Patricia, Maher Cormac O
Department of Neurosurgery, University of Michigan, Ann Arbor, Mich., USA.
Pediatr Neurosurg. 2013;49(1):55-9. doi: 10.1159/000355417. Epub 2013 Oct 29.
Using an illustrative case of a presumed pontine unidentified bright object (UBO) with spontaneous lesion regression over 2 years, we review the importance of including UBOs in the differential diagnosis of children with confirmed or possible neurofibromatosis type 1 (NF1) who present with diffuse pontine enlargement and T2-weighted changes on MRI. Asymptomatic children with presumed NF1 and diffuse pontine lesions should not be treated with radiation and should not be biopsied. Prior reports of good prognosis associated with pontine glioma in patients with NF1 may have been unrecognized UBOs in some cases.
通过一个推测为脑桥未明确高信号灶（UBO）且病变在2年内自发消退的典型病例，我们回顾了在对确诊或可能患有1型神经纤维瘤病（NF1）且MRI显示脑桥弥漫性增大和T2加权像改变的儿童进行鉴别诊断时，将UBO纳入考虑的重要性。无症状且推测患有NF1并伴有脑桥弥漫性病变的儿童不应接受放疗，也不应进行活检。先前关于NF1患者脑桥胶质瘤预后良好的报道，在某些情况下可能是未被识别的UBO。
