Pan Fangfang, Englert Ulli
Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
Acta Crystallogr C. 2013 Nov;69(Pt 11):1217-20. doi: 10.1107/S0108270113025936. Epub 2013 Oct 19.
A new polymorph is reported of the pharmaceutically active sulfapyridine derivative, N-(6-methylpyridin-2-yl)mesitylenesulfonamide, in the zwitterionic form 2-methyl-6-{[(2,4,6-trimethylbenzene)sulfonyl]azanidyl}pyridin-1-ium, C15H18N2O2S. The observed dimorphism is solvent dependent. The phase described previously [Beloso, Castro, García-Vázquez, Pérez-Lourido, Romero & Sousa (2003). Z. Anorg. Allg. Chem. 629, 275-284] crystallizes from ethanol and several other organic solvents, whereas the new form described here is obtained as a phase-pure product from methanol. The molecules in both dimorphic phases are very similar and adopt the conformation which is also predicted for an individual molecule by force field calculations. However, the two forms differ in their packing and hydrogen bonding. Results from solvent-assisted grinding indicate that the new form is less stable than the previously published phase.
据报道，具有药物活性的磺胺吡啶衍生物N-(6-甲基吡啶-2-基)均三甲苯磺酰胺存在一种新的多晶型物，呈两性离子形式，即2-甲基-6-{[(2,4,6-三甲基苯)磺酰基]氮基}吡啶-1-鎓，化学式为C15H18N2O2S。观察到的二态性取决于溶剂。先前描述的相[贝洛索、卡斯特罗、加西亚-巴斯克斯、佩雷斯-洛里多、罗梅罗和苏萨(2003年)。《德国应用化学》629, 275 - 284]从乙醇和其他几种有机溶剂中结晶出来，而这里描述的新形式是从甲醇中获得的纯相产物。两种双晶相中的分子非常相似，采用的构象也通过力场计算预测为单个分子的构象。然而，这两种形式在堆积和氢键方面有所不同。溶剂辅助研磨的结果表明，新形式比先前发表的相稳定性更低。
