染料木黄酮与异烟酰胺的1:2共晶体：晶体结构和 Hirshfeld 表面分析
A 1:2 cocrystal of genistein with isonicotinamide: crystal structure and Hirshfeld surface analysis.
作者信息
Sowa Michał, Slepokura Katarzyna, Matczak-Jon Ewa
机构信息
Department of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, Wrocław 50-370, Poland.
出版信息
Acta Crystallogr C. 2013 Nov;69(Pt 11):1267-72. doi: 10.1107/S0108270113029545. Epub 2013 Oct 31.
Genistein, a naturally occurring polyphenolic compound, was combined with isonicotinamide, a pharmaceutically acceptable coformer, to yield a 1:2 cocrystal [systematic name: 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one-pyridine-4-carboxamide (1/2)], C15H10O5·2C6H6N2O. The molecules in the cocrystalline phase are present in their neutral forms, and assemble a molecular layer by means of hydrogen bonding.
染料木黄酮是一种天然存在的多酚类化合物，它与烟酰胺（一种药学上可接受的共结晶形成物）结合，生成一种1:2的共晶体[系统名称：5,7-二羟基-3-(4-羟基苯基)色原酮-吡啶-4-甲酰胺(1/2)]，化学式为C15H10O5·2C6H6N2O。共晶相中的分子以中性形式存在，并通过氢键形成分子层。
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