Zeng Xian-Tao, Deng Ai-Ping, Li Cheng, Xia Ling-Yun, Niu Yu-Ming, Leng Wei-Dong
Department of Stomatology, Taihe Hospital and School of Stomatology, Hubei University of Medicine, Shiyan, Hubei Province, People's Republic of China.
PLoS One. 2013 Oct 23;8(10):e79017. doi: 10.1371/journal.pone.0079017. eCollection 2013.
Many epidemiological studies have found a positive association of periodontal disease (PD) with risk of head and neck cancer (HNC), but the findings are varied or even contradictory. In this work, we performed a meta-analysis to ascertain the relationship between PD and HNC risk.
We searched the PubMed, Embase, and Cochrane Library databases for relevant observational studies on the association between PD and HNC risk published up to March 23, 2013. Data from the included studies were extracted and analyzed independently by two authors. Meta-analysis was performed using RevMan 5.2 software.
We obtained seven observational studies involving two cohort and six case-control studies. Random-effects meta-analysis indicated a significant association between PD and HNC risk (odds ratio = 2.63, 95% confidence interval = 1.1.68 - 4.14; p < 0.001), with sensitivity analysis showing that the result was robust. Subgroup analyses based on adjustment for covariates, study design, PD assessment, tumor site, and ethnicity also revealed a significant association.
Based on currently evidence, PD is probably a significant and independent risk factor of HNC.
许多流行病学研究发现牙周病（PD）与头颈癌（HNC）风险之间存在正相关，但研究结果各不相同，甚至相互矛盾。在本研究中，我们进行了一项荟萃分析，以确定牙周病与头颈癌风险之间的关系。
我们检索了PubMed、Embase和Cochrane图书馆数据库，查找截至2013年3月23日发表的关于牙周病与头颈癌风险关联的相关观察性研究。纳入研究的数据由两位作者独立提取和分析。使用RevMan 5.2软件进行荟萃分析。
我们获得了7项观察性研究，其中包括2项队列研究和6项病例对照研究。随机效应荟萃分析表明，牙周病与头颈癌风险之间存在显著关联（优势比=2.63，95%置信区间=1.68 - 4.14；p<0.001），敏感性分析表明结果稳健。基于协变量调整、研究设计、牙周病评估、肿瘤部位和种族的亚组分析也显示出显著关联。
根据目前的证据，牙周病可能是头颈癌的一个重要独立危险因素。
Zotero 插件
