使用肽基脯氨酰硫酯研究天然化学连接。
Examination of native chemical ligation using peptidyl prolyl thioesters.
机构信息
Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Shomachi, Tokushima 770-8505, Japan.
出版信息
Chem Commun (Camb). 2014 Jan 4;50(1):58-60. doi: 10.1039/c3cc47228k. Epub 2013 Nov 6.
PMID:24195110
Abstract
Peptidyl prolyl thioesters, which have been regarded as too unreactive for practical use in native chemical ligations (NCLs), were proven to be versatile reagents in peptide coupling. Tuning the reactivity of prolyl thioesters enabled a one-pot/sequential NCL reaction based on kinetically controlled ligation.
摘要
肽基脯氨酰硫酯曾被认为在天然化学连接（NCL）中反应性过差而不实用，但现已被证明是肽偶联中的多功能试剂。调节脯氨酰硫酯的反应性，可使基于动力学控制连接的一锅/顺序 NCL 反应成为可能。
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