Atta ur Rehman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan,
Mol Biol Rep. 2014 Jan;41(1):225-32. doi: 10.1007/s11033-013-2855-1. Epub 2013 Nov 6.
MicroRNAs (miRNAs) are short 20-22 nucleotide non-coding RNA sequences. Recently identified, these are novel regulators of gene expression at translational level as well as transcriptional level. Alteration in miRNAs level has been observed in a number of human diseases and studies have been conducted on the effect of altered expression level of miRNAs on the development and progression of different diseases. The miRNAs can be used as molecular biomarkers in a number of diseases. Also, miRNAs are promising in providing a new platform for molecular therapeutics of previously incurable diseases. This review will focus on the introduction, recent advances in the field of miRNA and its importance in some human disorders.
微小 RNA（miRNAs）是 20-22 个核苷酸长的非编码 RNA 序列。这些最近才被发现，是在翻译水平以及转录水平上调节基因表达的新型调控因子。在许多人类疾病中观察到了 miRNAs 水平的改变，并且已经对 miRNA 表达水平改变对不同疾病的发生和发展的影响进行了研究。miRNAs 可以作为许多疾病的分子生物标志物。此外，miRNAs 在为以前无法治愈的疾病提供新的分子治疗平台方面具有广阔的前景。这篇综述将重点介绍 miRNA 的介绍、该领域的最新进展及其在一些人类疾病中的重要性。
