Paspala Syed Ab, Vishwakarma Sandeep K, Murthy Tenneti Vrk, Rao Thiriveedi N, Khan Aleem A
PAN Research Foundation, CARE, Hyderabad, India ; The Institute of Medical Sciences, Hyderabad, India.
Stem Cells Cloning. 2012 Sep 25;5:15-27. doi: 10.2147/SCCAA.S28477.
Stem cell transplantation for spinal cord injury (SCI) along with new pharmacotherapy research offers the potential to restore function and ease the associated social and economic burden in the years ahead. Various sources of stem cells have been used in the treatment of SCI, but the most convincing results have been obtained with neural progenitor cells in preclinical models. Although the use of cell-based transplantation strategies for the repair of chronic SCI remains the long sought after holy grail, these approaches have been to date the most successful when applied in the subacute phase of injury. Application of cell-based strategies for the repair and regeneration of the chronically injured spinal cord will require a combinational strategy that may need to include approaches to overcome the effects of the glial scar, inhibitory molecules, and use of tissue engineering strategies to bridge the lesion. Nonetheless, cell transplantation strategies are promising, and it is anticipated that the Phase I clinical trials of some form of neural stem cell-based approach in SCI will commence very soon.
脊髓损伤（SCI）的干细胞移植以及新的药物治疗研究为未来恢复功能、减轻相关社会和经济负担提供了可能。多种干细胞来源已被用于SCI治疗，但在临床前模型中，神经祖细胞取得了最令人信服的结果。尽管基于细胞的移植策略用于修复慢性SCI仍是长期以来追求的圣杯，但这些方法迄今为止在损伤亚急性期应用时最为成功。将基于细胞的策略应用于慢性损伤脊髓的修复和再生需要一种联合策略，可能需要包括克服胶质瘢痕、抑制分子影响的方法，以及使用组织工程策略来桥接损伤部位。尽管如此，细胞移植策略很有前景，预计某种形式的基于神经干细胞的方法用于SCI的I期临床试验将很快启动。
