Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Thorac Surg Clin. 2013 Nov;23(4):525-33. doi: 10.1016/j.thorsurg.2013.07.008.
This article focuses on adjuvant (postoperative) strategies for locally advanced esophageal cancers. Results of completed phase III trials of postoperative therapy for locally advanced adenocarcinomas and squamous cell carcinomas (SCCs) of the esophagus and gastroesophageal (GE) junction are summarized. Several postoperative and perioperative strategies have been shown to improve survival by approximately 15% when compared with surgery alone for adenocarcinomas of the esophagus and GE junction. On the other hand, all proven strategies for resectable SCCs involve preoperative treatment, and there are no validated strategies for the postoperative treatment of SCC.
本文重点介绍局部晚期食管癌的辅助（术后）策略。总结了已完成的局部晚期腺癌和食管及胃食管交界处（GEJ）鳞癌（SCC）术后治疗的 III 期临床试验结果。与单纯手术相比，几种术后和围手术期策略可使食管和 GEJ 腺癌的生存率提高约 15%。另一方面，所有可切除 SCC 的已证实策略均涉及术前治疗，并且术后 SCC 治疗尚无有效的策略。
