Ormoz Psychiatric Hospital, Department of Clinical Pharmacy, Slovenia, Ptujska Cesta 33, Ormoz, Slovenia.
Gen Hosp Psychiatry. 2013 Nov-Dec;35(6):680.e5-6. doi: 10.1016/j.genhosppsych.2013.03.022. Epub 2013 Apr 28.
Clozapine-induced fever has been reported frequently, but clozapine-induced elevated serum C-reactive protein (S-CRP) over 100 mg/L with early onset, without associated myocarditis, has not been reported in the literature. In this case report, we present a case of an 80-year-old Slovenian female with dementia and psychotic symptoms who developed elevated S-CRP (122 mg/L) and fever (38.2 °C) on the seventh day with 25 mg of clozapine daily, which improved after clozapine discontinuation. The patient did not have symptoms and signs of infection. This case report can be used to remind clinicians of keeping in mind the potential of clozapine associated with very high elevated S-CRP with fever, which can be easily confused with more serious conditions.
氯氮平引起的发热已被频繁报道，但氯氮平引起的血清 C 反应蛋白（S-CRP）升高超过 100mg/L 且早期发病，同时不伴有心肌炎，在文献中尚未报道。在本病例报告中，我们报告了一例 80 岁斯洛文尼亚女性痴呆症和精神病症状患者，每天服用 25 毫克氯氮平后第 7 天出现 S-CRP（122mg/L）升高和发热（38.2°C），停药后改善。患者没有感染的症状和体征。本病例报告可用于提醒临床医生注意氯氮平相关的非常高的 S-CRP 升高伴发热的潜在风险，这很容易与更严重的疾病混淆。
