抗精神病药对精神分裂症患者细胞因子血药浓度的影响：一项荟萃分析。
Antipsychotics' effects on blood levels of cytokines in schizophrenia: a meta-analysis.
机构信息
Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, Canada.
出版信息
Schizophr Res. 2013 Dec;151(1-3):43-7. doi: 10.1016/j.schres.2013.10.011. Epub 2013 Nov 4.
OBJECTIVES
Evidence-based medicine suggests that schizophrenia is associated with an inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic treatment has yet to be determined.
METHODS
A systematic quantitative review of the effects of antipsychotics on peripheral cytokine levels in schizophrenia was performed, using follow-up studies providing in vivo cytokine assessments before and after treatment.
RESULTS
We retrieved 23 studies (total of 762 subjects) which showed that antipsychotic treatment significantly increases plasma levels of soluble interleukin-2 receptor and reduces the plasma levels of interleukin-1β and interferon-γ.
CONCLUSIONS
These results show that antipsychotics produce anti-inflammatory effects in schizophrenia.
目的
循证医学表明精神分裂症与炎症综合征有关，但抗精神病药物治疗使该综合征正常化的程度尚未确定。
方法
使用提供治疗前后体内细胞因子评估的随访研究，对精神分裂症患者外周细胞因子水平受抗精神病药物影响的效果进行系统的定量综述。
结果
我们检索到 23 项研究（共 762 名受试者），表明抗精神病药物治疗可显著增加血浆可溶性白细胞介素-2 受体水平，并降低白细胞介素-1β和干扰素-γ的血浆水平。
结论
这些结果表明抗精神病药物在精神分裂症中具有抗炎作用。
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