Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Int J Mol Sci. 2013 Nov 6;14(11):21997-2010. doi: 10.3390/ijms141121997.
Metabolic syndrome (MetS) and albuminuria increase cardiovascular risk. However, in occupational drivers, the clinical significance of albuminuria and its association with MetS remain unclear. We investigated the prevalence of MetS, albuminuria and cardiovascular risk, and its associated risk factors in occupational drivers;
441 occupational drivers and 432 age- and sex-stratified matched counterpart controls were enrolled. MetS was defined using Adult Treatment Panel III for Asians. Albuminuria was defined as urine albumin-to-creatinine ratio ≥ 30 mg/g. Cardiovascular disease risk was evaluated by Framingham Risk Score (FRS);
A significantly higher prevalence of MetS (43.1% vs. 25.5%, p < 0.001), albuminuria (12.0% vs. 5.6%, p = 0.001) and high FRS risk ≥ 10% of 10-year risk (46.9% vs. 35.2%, p < 0.001) was found in occupational drivers compared with their counterpart controls. Multiple logistic regression analysis showed that old age, a history of diabetes, gout and betel nut chewing, less exercise and albuminuria (odds ratio [OR], 2.75; p = 0.01) were risk factors for MetS, while a history of renal disease, diabetes and hypertension, and MetS (OR, 2.28; p = 0.01) were risk factors for albuminuria in occupational drivers;
Our study demonstrated that MetS and albuminuria were public health problems in occupational drivers. An education program for promoting healthy lifestyle and a regular occupational health visit for early detection and interventions should be established.
代谢综合征（MetS）和白蛋白尿增加心血管风险。然而，在职业驾驶员中，白蛋白尿的临床意义及其与 MetS 的关系尚不清楚。我们研究了职业驾驶员中 MetS、白蛋白尿和心血管风险的患病率及其相关危险因素；
纳入了 441 名职业驾驶员和 432 名年龄和性别分层匹配的对照组。MetS 采用亚洲成年人治疗小组 III 进行定义。白蛋白尿定义为尿白蛋白/肌酐比值≥30mg/g。心血管疾病风险采用 Framingham 风险评分（FRS）进行评估；
与对照组相比，职业驾驶员 MetS（43.1%比 25.5%，p<0.001）、白蛋白尿（12.0%比 5.6%，p=0.001）和高 FRS 风险（10 年风险≥10%，46.9%比 35.2%，p<0.001）的患病率显著更高。多因素 logistic 回归分析显示，年龄较大、糖尿病史、痛风和嚼槟榔、运动较少和白蛋白尿（比值比[OR]，2.75；p=0.01）是 MetS 的危险因素，而肾脏病史、糖尿病和高血压以及 MetS（OR，2.28；p=0.01）是职业驾驶员白蛋白尿的危险因素；
我们的研究表明，MetS 和白蛋白尿是职业驾驶员的公共卫生问题。应制定促进健康生活方式的教育计划和定期职业健康检查，以进行早期发现和干预。
