Ernst Andreas Max, Brügger Britta
Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Biochim Biophys Acta. 2014 May;1841(5):665-70. doi: 10.1016/j.bbalip.2013.10.016. Epub 2013 Nov 5.
The diversity of the transmembranome of higher eukaryotes is matched by an enormous diversity of sphingolipid classes and molecular species. The intrinsic properties of sphingolipids are not only suited for orchestrating lateral architectures of biological membranes, but their molecular distinctions also allow for the evolution of protein motifs specifically recognising and interacting with individual lipids. Although various reports suggest a role of sphingolipids in membrane protein function, only a few cases have determined the specificity of these interactions. In this review we discuss examples of specific protein-sphingolipid interactions for which a modulator-like dependency on sphingolipids was assigned to specific proteins. These novel functions of sphingolipids in specific protein-lipid assemblies contribute to the complexity of the sphingolipid classes and other molecular species observed in animal cells. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology.
高等真核生物跨膜组的多样性与鞘脂种类和分子物种的巨大多样性相匹配。鞘脂的内在特性不仅适合于构建生物膜的侧向结构，而且它们的分子差异还允许进化出专门识别单个脂质并与之相互作用的蛋白质基序。尽管各种报道表明鞘脂在膜蛋白功能中起作用，但只有少数情况确定了这些相互作用的特异性。在本综述中，我们讨论了特定蛋白质 - 鞘脂相互作用的例子，其中特定蛋白质对鞘脂具有类似调节剂的依赖性。鞘脂在特定蛋白质 - 脂质组装体中的这些新功能导致了在动物细胞中观察到的鞘脂种类和其他分子物种的复杂性。本文是名为“鞘脂生物学新前沿”的特刊的一部分。
