Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan.
Org Biomol Chem. 2014 Jan 7;12(1):119-22. doi: 10.1039/c3ob41938j. Epub 2013 Nov 8.
Cinchona-alkaloid-urea-based bifunctional organocatalysts facilitate the catalytic asymmetric synthesis of chroman derivatives via an intramolecular oxy-Michael addition reaction. Phenol derivatives bearing an easily available (E)-α,β-unsaturated ketone or a thioester moiety are useful substrates for the title transformation. This method represents a facile synthesis of various optically active 2-substituted chromans in high yield.
基于金鸡纳生物碱-脲的双功能有机催化剂通过分子内氧迈克尔加成反应促进了色满衍生物的催化不对称合成。具有易得的（E）-α,β-不饱和酮或硫酯部分的酚衍生物是该转化的有用底物。该方法代表了各种光学活性 2-取代色满的简便合成，产率高。
