介导金鱼（Carassius auratus）促性腺激素和生长激素释放的细胞内机制。
Intracellular mechanisms mediating gonadotropin and growth hormone release in the goldfish, Carassius auratus.
机构信息
Department of Zoology, University of Alberta, Edmonton, Alberta, Canada, T6G2E9.
出版信息
Fish Physiol Biochem. 1993 Jul;11(1-6):25-33. doi: 10.1007/BF00004547.
Evidence for the involvement of Ca(2+), protein kinase C, cAMP, and arachidonic acid metabolism in mediating gonadotropin (GTH) and growth hormone (GH) release in the goldfish is reviewed. Models for the signal transduction pathways mediating GTH-releasing hormone (GnRH) and dopamine actions on GTH and GH secretion are postulated. A novel hypothesis that two GnRHs which bind to the same receptor type activate different transduction cascade in two different cell types (GTH vs. GH) as well as within the same cell type (GTH) is presented.
本文综述了参与介导鱼类促性腺激素（GTH）和生长激素（GH）释放的 Ca(2+)、蛋白激酶 C、cAMP 和花生四烯酸代谢的证据。提出了介导促性腺激素释放激素（GnRH）和多巴胺对 GTH 和 GH 分泌作用的信号转导途径的模型。本文提出了一个新的假设，即两种结合相同受体类型的 GnRH 可在两种不同的细胞类型（GTH 与 GH）以及同一细胞类型（GTH）中激活不同的转导级联。
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