钙离子在非洲鲶鱼（Clarias gariepinus）中促性腺激素释放激素对促性腺激素分泌作用中的角色。
Role of calcium ions in action of gonadotropin-releasing hormone on gonadotropin secretion in the African catfish, Clarias gariepinus.
作者信息
van Asselt L A, Goos H J, van Dijk W, Braas J
机构信息
Department of Experimental Zoology, University of Utrecht, The Netherlands.
出版信息
Gen Comp Endocrinol. 1989 Oct;76(1):46-52. doi: 10.1016/0016-6480(89)90031-2.
The aim of the present study was to establish the role of calcium ions in the mechanism of action of gonadotropin-releasing hormone (GnRH) in stimulating gonadotropin (GTH) release in the African catfish, Clarias gariepinus. For that purpose, GTH release from pituitary fragments was monitored in a perifusion system. GTH release, induced by the GnRH analog Buserelin, was strongly diminished in the absence of Ca2+, as well as in the presence of the Ca2+ channel antagonist nifedipine. In addition, the Ca2+ ionophore A23187 stimulated GTH secretion in the absence of GnRH. These results indicate that calcium ions play an intermediate role in the mechanism of action of GnRH in the African catfish.
本研究的目的是确定钙离子在促性腺激素释放激素（GnRH）刺激非洲鲶鱼（Clarias gariepinus）促性腺激素（GTH）释放的作用机制中所起的作用。为此，在灌流系统中监测垂体碎片释放的GTH。在没有Ca2+以及存在Ca2+通道拮抗剂硝苯地平的情况下，GnRH类似物布舍瑞林诱导的GTH释放显著减少。此外，Ca2+离子载体A23187在没有GnRH的情况下刺激GTH分泌。这些结果表明，钙离子在非洲鲶鱼GnRH的作用机制中起中间作用。
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