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编码两种胰蛋白酶抑制剂的序列出现在惊人相似的基因组环境中。

Sequences encoding two trypsin inhibitors occur in strikingly similar genomic environments.

作者信息

Kingston I B, Anderson S

出版信息

Biochem J. 1986 Jan 15;233(2):443-50. doi: 10.1042/bj2330443.

DOI:10.1042/bj2330443
PMID:2420326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1153045/
Abstract

The nucleotide sequences of two approx. 4 kilobase pair segments of the bovine genome are presented. One segment contains a coding region for bovine pancreatic trypsin inhibitor (BPTI) and the other segment contains a coding region for a BPTI homologue. The two 4 kilobase pair sequences are strikingly similar over approx. 3.4 kilobase pairs of their sequence, including putative intron sequences, suggesting that they have evolved from a gene duplication event.

摘要

本文呈现了牛基因组中两个约4千碱基对片段的核苷酸序列。一个片段包含牛胰蛋白酶抑制剂（BPTI）的编码区，另一个片段包含BPTI同源物的编码区。这两个4千碱基对序列在其约3.4千碱基对的序列上，包括推定的内含子序列，惊人地相似，表明它们是由基因复制事件进化而来的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/1153045/3066af118099/biochemj00287-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/1153045/14b0a1e4c7ef/biochemj00287-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/1153045/3066af118099/biochemj00287-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/1153045/14b0a1e4c7ef/biochemj00287-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1d4/1153045/3066af118099/biochemj00287-0136-a.jpg

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THE BASIC TRYPSIN INHIBITOR OF BOVINE PANCREAS. IV. THE LINEAR SEQUENCE OF THE 58 AMINO ACIDS.牛胰基本胰蛋白酶抑制剂。IV. 58个氨基酸的线性序列
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