Nahorski S R
Arzneimittelforschung. 1985;35(12A):1886-90.
Activation of several receptors by neurotransmitters, hormones and local mediators stimulate inositol phospholipid breakdown by phospholipase C in a variety of tissues. Inositol trisphosphate and diacylglycerol are probable second messengers for these receptors with the former mobilizing intracellularly bound calcium and the latter stimulating a cyclic nucleotide independent protein kinase C. Activation of these receptors also often leads to a stimulation of arachidonic acid metabolism generating prostaglandins, leukotrienes etc. In the brain, several neurotransmitters including neuropeptides stimulate inositol phospholipid breakdown by interacting with receptors closely coupled to phospholipase C. Furthermore, depolarization of cerebral cortical slices also stimulates inositol phospholipid breakdown by opening voltage- and dihydropyridine-sensitive calcium channels.
神经递质、激素和局部介质对多种受体的激活，会刺激多种组织中的磷脂酶C分解肌醇磷脂。肌醇三磷酸和二酰基甘油可能是这些受体的第二信使，前者可动员细胞内结合的钙，后者可刺激一种不依赖环核苷酸的蛋白激酶C。这些受体的激活通常还会刺激花生四烯酸代谢，生成前列腺素、白三烯等。在大脑中，包括神经肽在内的几种神经递质通过与紧密偶联磷脂酶C的受体相互作用，刺激肌醇磷脂分解。此外，大脑皮层切片的去极化也会通过打开对电压和二氢吡啶敏感的钙通道来刺激肌醇磷脂分解。
