Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, RMSB 3075, 1600 NW 10th Avenue, Miami, FL, 33136, USA,
Immunol Res. 2013 Dec;57(1-3):172-84. doi: 10.1007/s12026-013-8455-2.
Myeloid derived suppressor cells (MDSCs), a heterogeneous population of myeloid progenitors, are recognized as a key element in tumor escape and progression. The importance of MDSCs in human malignancies has been demonstrated in recent years, and new approaches targeting their suppressive/tolerogenic action are currently being tested in both preclinical model and clinical trials. However, emerging evidence suggests that MDSCs may play a prominent role as regulator of the physiologic, the chronic, and the pathologic immune responses. This review will focus on the biology of MDSC in light of these new findings and the possible role of this myeloid population not only in the progression of the tumor but also in its initiation.
髓系来源的抑制细胞（MDSCs）是髓系祖细胞的异质性群体，被认为是肿瘤逃逸和进展的关键因素。近年来，MDSCs 在人类恶性肿瘤中的重要性已经得到证实，目前正在临床前模型和临床试验中测试针对其抑制/耐受作用的新方法。然而，新出现的证据表明，MDSC 可能作为生理、慢性和病理免疫反应的调节剂发挥突出作用。本综述将根据这些新发现重点讨论 MDSC 的生物学特性，以及这种髓系细胞群体不仅在肿瘤进展中，而且在肿瘤起始中可能发挥的作用。
