与腺鳞癌相关的高钙血症：启动姑息治疗的一个理由。
Hypercalcemia associated with adenosquamous pancreatic carcinoma: a reason to initiate palliative treatment.
作者信息
López-Tomassetti-Fernández Eudaldo M, Favre-Rizzo Julián, Delgado-Plasencia Luciano, Hernández-Hernández Juan Ramón
出版信息
Rev Esp Enferm Dig. 2013 Aug;105(7):425-8. doi: 10.4321/s1130-01082013000700009.
BACKGROUND
hypercalcemia in patients with diagnosed carcinoma has predominantly a humoral basis mediated by parathyroid hormone-related protein (PTH-rP). Among the reported cases, hypercalcemia associated with the majority of abdominal malignancies indicates an advanced stage of disease.
CASE REPORT
we present a case of a 78-year-old patient with an adenosquamous pancreatic carcinoma associated with humoral hypercalcemia mediated by PTH-rP.
CONCLUSION
in this case, demonstration of unexpectantly rapid increase in calcium serum correlated with aggressive tumor growth led us to raise the hypothesis that PTH-rP could be a mediator of invasion and dissemination secreted by some tumors, and probably indicates the appropriate time to initiate palliative treatment.
背景
已确诊的癌症患者出现高钙血症主要是由甲状旁腺激素相关蛋白（PTH-rP）介导的体液因素所致。在已报道的病例中，大多数腹部恶性肿瘤相关的高钙血症提示疾病处于晚期。
病例报告
我们报告一例78岁患有腺鳞癌的胰腺癌患者，其高钙血症由PTH-rP介导的体液因素引起。
结论
在该病例中，血清钙意外快速升高与肿瘤侵袭性生长相关，这使我们提出假说，即PTH-rP可能是某些肿瘤分泌的侵袭和扩散介质，这可能提示开始姑息治疗的合适时机。
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