基底神经节的生物化学与帕金森病
The biochemistry of the basal ganglia and Parkinson's disease.
作者信息
Curzon G
出版信息
Postgrad Med J. 1977 Dec;53(626):719-25. doi: 10.1136/pgmj.53.626.719.
Abstract
The metabolic pathways for five transmitters in the basal ganglia are briefly described; the results of determinations of their concentrations, of their rate-limiting enzymes and of their degradation products are summarized. The changes found in Parkinson's disease are described. While dopamine synthesis in the basal ganglia is defective in this condition, abnormalities of other transmitters occur, and their possible significance is discussed.
摘要
简要描述了基底神经节中五种神经递质的代谢途径；总结了它们的浓度、限速酶及其降解产物的测定结果。描述了帕金森病中发现的变化。虽然在这种情况下基底神经节中的多巴胺合成存在缺陷，但其他神经递质也出现异常，并讨论了它们可能的意义。
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SUBSTANTIA NIGRA AND PARKINSONISM.黑质与帕金森病
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