Hara Y, Aono M, Maeda K, Akamine A, Furukawa T, Yoshimura S
J Periodontol. 1986 Feb;57(2):100-3. doi: 10.1902/jop.1986.57.2.100.
A case of prepubertal periodontitis was observed and examined immunohistologically with peroxidase-antiperoxidase staining. The patient was an 11-year and 7-month-old Japanese girl, well-developed and well-nourished. Her parents were first cousins. Her chief complaint was the loosening and loss of the permanent teeth. There was a similar history of primary dentition. Her remaining permanent teeth were loosened with severe alveolar bone loss, but calculus deposit was minimal. Significantly, there was no palmar-plantar hyperkeratosis. General examination showed normal data except for the increase of the immunoglobulin concentrations. In neutrophil function tests chemotaxis was depressed, although phagocytosis, random migration and superoxide production were within normal limits. Histologically, neutrophils were seen in the gingival tissue and other findings were also similar to those of adult periodontitis. In immunohistological examination, IgG-bearing cells which mostly consisted of plasma cells predominated in the lesion. Considering the past history, the immunodeficiency and the absence of palmar-plantar hyperkeratosis, the case was diagnosed as prepubertal periodontitis.
观察到一例青春期前牙周炎病例，并采用过氧化物酶-抗过氧化物酶染色法进行免疫组织学检查。患者是一名11岁7个月大的日本女孩，发育良好，营养充足。她的父母是近亲。她的主要诉求是恒牙松动和脱落。乳牙列有类似病史。她剩余的恒牙松动，伴有严重的牙槽骨吸收，但牙石沉积极少。值得注意的是，没有掌跖角化过度。全身检查除免疫球蛋白浓度升高外，其他数据均正常。在中性粒细胞功能测试中，趋化作用受到抑制，尽管吞噬作用、随机迁移和超氧化物产生均在正常范围内。组织学上，在牙龈组织中可见中性粒细胞，其他表现也与成人牙周炎相似。在免疫组织学检查中，病变中以IgG阳性细胞为主，这些细胞大多由浆细胞组成。考虑到既往病史、免疫缺陷以及掌跖角化过度的缺失，该病例被诊断为青春期前牙周炎。
