来自患有恰加斯病小鼠脾脏的含聚腺苷酸（Poly(A)）RNA在体外引发巨噬细胞对克氏锥虫的抗性。
Poly(A)-containing RNA from the spleens of mice with Chagas' disease triggers in vitro macrophage resistance to Trypanosoma cruzi.
作者信息
Bertolini M C, De Lucca F L
出版信息
J Protozool. 1986 Feb;33(1):81-4. doi: 10.1111/j.1550-7408.1986.tb05562.x.
Abstract
Mouse peritoneal macrophages exposed to the RNA from the spleens of mice infected with Trypanosoma cruzi (iRNA) exhibit enhanced resistance to this parasite. The poly(A)-containing iRNA was found to be the active fraction. No such activity was observed in macrophages incubated with RNA from normal mice (nRNA) or with synthetic poly A.
摘要
暴露于感染克氏锥虫的小鼠脾脏RNA（iRNA）的小鼠腹膜巨噬细胞，对这种寄生虫表现出增强的抗性。发现含聚腺苷酸的iRNA是活性组分。在用正常小鼠的RNA（nRNA）或合成聚腺苷酸孵育的巨噬细胞中未观察到这种活性。
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