Sei Y, Yasuda K, Hara A, Yasuda K, Yokoyama M M
J Clin Lab Immunol. 1986 Feb;19(2):71-5.
We studied cell surface antigens on fresh and cultured peripheral blood lymphocytes (PBL) of healthy HTLV-I carriers. OKT4, OKT8 and OKIa1-positive cells were found to be within the normal range as compared with controls both in fresh and in cultured PBL. The percentage of Tac positive cells in HTLV-I carriers was shown to be higher in fresh PBL than that of controls. Furthermore the value increased significantly during cell culture in vitro and large blastoid cells appeared. The results suggested that HTLV-I proliferation in infected lymphocytes is activated in a serum-free environment and that small resting lymphocytes are transformed into Tac-positive large blastoid cells.
我们研究了健康的人类嗜T淋巴细胞病毒I型（HTLV-I）携带者新鲜的和培养后的外周血淋巴细胞（PBL）上的细胞表面抗原。与对照组相比，无论是新鲜的还是培养后的PBL中，OKT4、OKT8和OKIa1阳性细胞均在正常范围内。结果显示，HTLV-I携带者新鲜PBL中Tac阳性细胞的百分比高于对照组。此外，在体外细胞培养过程中该数值显著增加，并且出现了大的母细胞样细胞。这些结果表明，在无血清环境中，感染淋巴细胞中的HTLV-I增殖被激活，并且静止的小淋巴细胞转化为Tac阳性的大母细胞样细胞。
