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采用简单的后外侧入路成功切除颅颈交界区的前侧和前外侧病变。

Successful resection of anterior and anterolateral lesions at the craniovertebral junction using a simple posterolateral approach.

机构信息

Dardinger Microneurosurgical Skull Base Laboratory, Department of Neurological Surgery, Ohio State University Medical Center, N1025 Doan Hall, 410 W. 10th Street, Columbus, OH 43210, USA; Department of Neurological Surgery, Cleveland Clinic, Cleveland, OH, USA.

Dardinger Microneurosurgical Skull Base Laboratory, Department of Neurological Surgery, Ohio State University Medical Center, N1025 Doan Hall, 410 W. 10th Street, Columbus, OH 43210, USA.

出版信息

J Clin Neurosci. 2014 Apr;21(4):616-22. doi: 10.1016/j.jocn.2013.06.010. Epub 2013 Aug 24.

Abstract

Tumors at the craniovertebral junction (CVJ) often present a challenge due to proximity to vital neurovascular structures. In the last few decades, many authors have proposed complex surgical approaches to access pathologies located anterior or anterolateral to the CVJ with the hopes of reducing morbidity. We propose that the simple posterolateral approach in a semi-sitting position can be used to resect most anterior and anterolateral CVJ tumors safely and effectively. We retrospectively reviewed the clinical series of 10 patients treated by the senior author using the posterolateral suboccipital approach to treat anterior or anterolateral CVJ pathologies. We describe our surgical techniques, outcomes, and present illustrative patients. Gross total resection was achieved in eight patients (80%). Good functional outcome (Glasgow Outcome Scale 4-5) was obtained in all patients. Preoperative symptoms and deficits were improved (78%) or stable (22%) in all patients. There was one (10%) surgical complication that was cerebrospinal fluid leak requiring reoperation. There was no permanent morbidity or mortality in this series. There were two (20%) medical complications including deep vein thrombosis and pulmonary embolus. There were three (30%) transient neurologic complications, dysphagia in two and dysarthria in one, all of which resolved completely in early follow-up. The majority of anterior or anterolateral CVJ lesions can be successfully removed using the simple posterolateral approach.

摘要

颅颈交界区(CVJ)的肿瘤由于靠近重要的神经血管结构,常常带来挑战。在过去的几十年中,许多作者提出了复杂的手术方法,以期减少发病率,从而能够到达 CVJ 前侧或前外侧的病变部位。我们提出,半坐卧位的简单后路入路可安全有效地切除大多数 CVJ 的前侧和前外侧肿瘤。我们回顾性分析了高级作者使用后路枕下入路治疗 10 例前侧或前外侧 CVJ 病变患者的临床系列。我们描述了我们的手术技术、结果,并介绍了有代表性的患者。8 例患者(80%)实现了大体全切除。所有患者的功能预后均良好(格拉斯哥预后量表 4-5)。所有患者的术前症状和缺陷均得到改善(78%)或稳定(22%)。有 1 例(10%)手术并发症为脑脊液漏,需要再次手术。本系列无永久性并发症或死亡。有 2 例(20%)医疗并发症,包括深静脉血栓形成和肺栓塞。有 3 例(30%)短暂性神经并发症,2 例为吞咽困难,1 例为构音障碍,所有患者在早期随访中均完全缓解。大多数 CVJ 的前侧或前外侧病变可通过简单的后路入路成功切除。

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