健康个体中导水管脑脊液搏动性受脑静脉流出受损的影响。

Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow.

作者信息

Beggs Clive B, Magnano Christopher, Shepherd Simon J, Marr Karen, Valnarov Vesela, Hojnacki David, Bergsland Niels, Belov Pavel, Grisafi Steven, Dwyer Michael G, Carl Ellen, Weinstock-Guttman Bianca, Zivadinov Robert

机构信息

Medical Biophysics Laboratory, University of Bradford, Bradford, UK.

出版信息

J Magn Reson Imaging. 2014 Nov;40(5):1215-22. doi: 10.1002/jmri.24468. Epub 2013 Nov 8.

DOI:10.1002/jmri.24468

PMID:24214844

Abstract

PURPOSE

To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and -negative healthy individuals using cine phase contrast imaging.

MATERIALS AND METHODS

Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled ≥2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes.

RESULTS

CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021).

CONCLUSION

CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individuals.

摘要