Department of Radiology Informatics and Statistics, Medical University of Gdansk, Gdansk, Poland.
Department of Physics, Lancaster University, Lancaster, UK.
Sci Rep. 2018 Feb 15;8(1):3057. doi: 10.1038/s41598-018-21038-0.
Abnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the SAS width within a wide range of frequencies from 0.005 to 2 Hz, with low frequencies studied in detail for the first time. From recordings in the resting state, we also demonstrate the relationships between SAS width in both hemispheres of the brain, and investigate how the SAS width dynamics is related to the blood pressure (BP). These investigations also revealed influences of age and SAS correlation on the dynamics of SAS width and its similarity with the BP. Combination of NIR-T/BSS and time-frequency analysis may open up new frontiers in the understanding and diagnosis of various neurodegenerative and ageing related diseases to improve diagnostic procedures and patient prognosis.
异常的脑脊液（CSF）脉动与多种疾病的患者有关，包括多发性硬化症和高血压。CSF 脉动导致蛛网膜下腔（SAS）宽度变化，可以通过近红外透射背散射探测（NIR-T/BSS）进行测量。本研究的目的是结合 NIR-T/BSS 和小波分析方法，在 0.005 至 2 Hz 的宽频率范围内描述 SAS 宽度的动力学，这是首次对低频进行详细研究。从休息状态的记录中，我们还证明了大脑两个半球之间的 SAS 宽度之间的关系，并研究了 SAS 宽度动力学与血压（BP）之间的关系。这些研究还揭示了年龄和 SAS 相关性对 SAS 宽度动力学及其与 BP 相似性的影响。NIR-T/BSS 和时频分析的结合可能为理解和诊断各种神经退行性和与年龄相关的疾病开辟新的前沿，以改善诊断程序和患者预后。
