阿尔茨海默病的口齿不清变异型脑脊液中tau 水平升高。
Increased cerebrospinal fluid tau levels in logopenic variant of Alzheimer's disease.
机构信息
Research Memory Center (CMRR), CHU Besançon, Besançon, France.
Research Memory Center (CMRR) Paris-Nord-Ile-de France, AP-HP, Université Paris Diderot, Paris, France.
出版信息
J Alzheimers Dis. 2014;39(3):611-6. doi: 10.3233/JAD-131382.
BACKGROUND
Patients with logopenic variant of primary progressive aphasia (lvPPA) display neuropathological differences from typical amnestic Alzheimer's disease (AD).
OBJECTIVE
The aim of the study was to compare cerebrospinal fluid (CSF) biomarker levels between patients with lvPPA due to AD (lvPPA-AD), non-logopenic forms of AD (nlAD), and amnestic mild cognitive impairment due to AD (aMCI-AD).
METHODS
CSF biomarker concentrations were assessed in 124 patients divided into three groups matched for age, level of education, center, and disease duration: lvPPA-AD (n = 30), nlAD (n = 67). and aMCI-AD (n = 27).
RESULTS
p-Tau181 levels were higher in the lvPPA-AD group than in the aMCI-AD group (p < 0.05). Total tau levels were higher in the lvPPA-AD group versus those in the nlAD (p < 0.05) and aMCI-AD (p < 0.001) groups.
CONCLUSIONS
These results suggest a more pronounced involvement of a taupathy in lvPPA-AD compared to aMCI-AD and a more important neuronal death in lvPPA-AD than in nlAD or aMCI-AD.
背景
患有失语法型原发性进行性失语症（lvPPA）的患者表现出与典型遗忘型阿尔茨海默病（AD）不同的神经病理学差异。
目的
本研究旨在比较 AD 所致 lvPPA（lvPPA-AD）、非失语法型 AD（nlAD）和 AD 所致遗忘型轻度认知障碍（aMCI-AD）患者的脑脊液（CSF）生物标志物水平。
方法
对 124 名患者的 CSF 生物标志物浓度进行评估，这些患者分为三组，年龄、教育程度、中心和疾病持续时间匹配：lvPPA-AD（n = 30）、nlAD（n = 67）和 aMCI-AD（n = 27）。
结果
lvPPA-AD 组 p-Tau181 水平高于 aMCI-AD 组（p < 0.05）。lvPPA-AD 组总 tau 水平高于 nlAD 组（p < 0.05）和 aMCI-AD 组（p < 0.001）。
结论
这些结果表明，与 aMCI-AD 相比，lvPPA-AD 中 taupathy 的参与更为明显，与 nlAD 或 aMCI-AD 相比，lvPPA-AD 中神经元死亡更为重要。
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