Nohmi M, Shinnick-Gallagher P, Gean P W, Gallagher J P, Cooper C W
Brain Res. 1986 Mar 5;367(1-2):346-50. doi: 10.1016/0006-8993(86)91616-1.
Recent data suggests that calcitonin (CT) and/or calcitonin gene-related peptide (CGRP) may be potential transmitters or modulators in the nervous system. The present study analyzed the effect of CT and CGRP on the neuronal membranes of cat parasympathetic ganglia of the urinary bladder. The related peptides prolonged the duration of the afterhyperpolarization of the action potential but had no effect on resting potential or input resistance. CT and CGRP enhanced the duration of a calcium spike recorded in the presence of agents blocking Na and K channels while under similar conditions forskolin, an activator of adenylate cyclase, did not affect the calcium spike. These data suggest that the neural mechanism of action of CT and CGRP is to prolong a calcium conductance and that these effects are not mediated through cyclic AMP.
近期数据表明，降钙素（CT）和/或降钙素基因相关肽（CGRP）可能是神经系统中的潜在递质或调节剂。本研究分析了CT和CGRP对猫膀胱副交感神经节神经元膜的影响。相关肽延长了动作电位后超极化的持续时间，但对静息电位或输入电阻没有影响。在存在阻断钠和钾通道的药物的情况下，CT和CGRP延长了记录的钙峰的持续时间，而在类似条件下，腺苷酸环化酶激活剂福斯高林对钙峰没有影响。这些数据表明，CT和CGRP的神经作用机制是延长钙电导，且这些作用不是通过环磷酸腺苷介导的。
