de Jong Pim A, Lammers Jan-Willem
UMC Utrecht, Utrecht.
Ned Tijdschr Geneeskd. 2013;157(46):A7019.
Screening for lung cancer with computed tomography (CT) appears to be highly effective. A large randomized trial in the United States reported a 7% reduction in all-cause mortality in patients screened by CT in comparison with those screened by chest radiography. The problem of dealing with the large number of pulmonary nodules and false positive test results could be solved by a protocol from the Dutch-Belgian lung cancer screening trial which proposes a strategy based on nodule volume and volumetry. Additional findings related to chronic obstructive pulmonary disease and cardiovascular disease are common in lung cancer screening and may provide an opportunity to increase screening benefits at minimal cost in the future. As CT is superior to radiography in lung cancer detection, CT seems the preferred imaging modality for case finding. As more trial results have to be awaited and cost-effectiveness and optimal screening strategy remain uncertain, CT lung cancer screening is not yet ready for implementation.
使用计算机断层扫描(CT)筛查肺癌似乎非常有效。美国一项大型随机试验报告称,与接受胸部X光筛查的患者相比,接受CT筛查的患者全因死亡率降低了7%。荷兰-比利时肺癌筛查试验的一项方案可以解决处理大量肺结节和假阳性检测结果的问题,该方案提出了一种基于结节体积和容积测量的策略。在肺癌筛查中,与慢性阻塞性肺疾病和心血管疾病相关的其他发现很常见,这可能为未来以最小成本提高筛查效益提供机会。由于CT在肺癌检测方面优于X光,CT似乎是用于病例发现的首选成像方式。由于还需要等待更多的试验结果,且成本效益和最佳筛查策略仍不确定,CT肺癌筛查尚未准备好实施。