CHI3L1 通过增强促炎/促肿瘤发生和血管生成因子的产生在癌症中发挥作用。
CHI3L1 plays a role in cancer through enhanced production of pro-inflammatory/pro-tumorigenic and angiogenic factors.
机构信息
Department of Biomedical Sciences, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
出版信息
Immunol Res. 2013 Dec;57(1-3):99-105. doi: 10.1007/s12026-013-8459-y.
Abstract
Elevated serum levels of a glycoprotein known as chitinase-3-like protein 1 (CHI3L1) have been correlated with poor prognosis and shorter survival of patients with cancer and inflammatory diseases. The biological and physiological functions of CHI3L1 in cancer have not yet been completely elucidated. In this review, we describe the role of CHI3L1 in inducing pro-inflammatory/pro-tumorigenic and angiogenic factors that could promote tumor growth and metastasis.
摘要
血清中一种名为壳三糖酶蛋白 3 样蛋白 1（CHI3L1）的糖蛋白水平升高与癌症和炎症性疾病患者的预后不良和生存期缩短相关。CHI3L1 在癌症中的生物学和生理学功能尚未完全阐明。在这篇综述中，我们描述了 CHI3L1 诱导促炎/促肿瘤发生和血管生成因子的作用，这些因子可促进肿瘤生长和转移。
相似文献
1
CHI3L1 plays a role in cancer through enhanced production of pro-inflammatory/pro-tumorigenic and angiogenic factors.CHI3L1 通过增强促炎/促肿瘤发生和血管生成因子的产生在癌症中发挥作用。
Immunol Res. 2013 Dec;57(1-3):99-105. doi: 10.1007/s12026-013-8459-y.
2
Chitinase 3 like 1 is associated with tumor angiogenesis in cervical cancer.几丁质酶3样蛋白1与宫颈癌中的肿瘤血管生成相关。
Int J Biochem Cell Biol. 2014 Jun;51:45-52. doi: 10.1016/j.biocel.2014.03.021. Epub 2014 Mar 29.
3
Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer.几丁质酶 3 样蛋白 1 促进结直肠癌中的巨噬细胞募集和血管生成。
Oncogene. 2012 Jun 28;31(26):3111-23. doi: 10.1038/onc.2011.498. Epub 2011 Nov 7.
4
YKL-40/CHI3L1 drives inflammation on the road of tumor progression.YKL-40/CHI3L1在肿瘤进展过程中引发炎症。
J Leukoc Biol. 2015 Dec;98(6):931-6. doi: 10.1189/jlb.3VMR0415-142R. Epub 2015 Aug 26.
5
Chitinase-3-like protein 1 protects skeletal muscle from TNFα-induced inflammation and insulin resistance.几丁质酶 3 样蛋白 1 可保护骨骼肌免受 TNFα 诱导的炎症和胰岛素抵抗。
Biochem J. 2014 May 1;459(3):479-88. doi: 10.1042/BJ20131151.
6
The expression of chitinase 3-like 1: a novel prognostic predictor for hepatocellular carcinoma.几丁质酶 3 样蛋白 1 的表达：一种用于预测肝细胞癌的新型预后标志物。
J Cancer Res Clin Oncol. 2013 Jun;139(6):1043-54. doi: 10.1007/s00432-013-1415-3. Epub 2013 Mar 23.
7
Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation.几丁质酶3样蛋白1调节内脏脂肪堆积和哮喘样Th2炎症。
Am J Respir Crit Care Med. 2015 Apr 1;191(7):746-57. doi: 10.1164/rccm.201405-0796OC.
8
Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis.几丁质酶3样蛋白1表达增加是非小细胞肺癌的预后标志物，与肿瘤血管生成相关。
Tumour Biol. 2015 Feb;36(2):901-7. doi: 10.1007/s13277-014-2690-6. Epub 2014 Oct 12.
9
Chitinase 3-Like-1 (CHI3L1): a putative disease marker at the interface of proteomics and glycomics.几丁质酶3样蛋白1（CHI3L1）：蛋白质组学与糖组学交叉领域的一种潜在疾病标志物。
Crit Rev Clin Lab Sci. 2008;45(6):531-62. doi: 10.1080/10408360802334743.
10
Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia.结肠上皮细胞中几丁质酶 3 样蛋白 1 的表达作为结肠炎相关肿瘤的一个潜在新型标志物。
Am J Pathol. 2011 Sep;179(3):1494-503. doi: 10.1016/j.ajpath.2011.05.038. Epub 2011 Jul 16.
引用本文的文献
1
Integrated multiomics and Mendelian randomization identify CHIT1 as a novel sepsis biomarker and therapeutic target.整合多组学和孟德尔随机化研究确定几丁质酶1（CHIT1）为一种新型脓毒症生物标志物和治疗靶点。
Sci Rep. 2025 May 5;15(1):15715. doi: 10.1038/s41598-025-99619-z.
2
Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models.乳腺退化的不同路径：揭示突然和逐渐退化的小鼠模型中的细胞动力学
Breast Cancer Res. 2025 Jan 3;27(1):1. doi: 10.1186/s13058-024-01933-3.
3
Host-defence caerin 1.1 and 1.9 peptides suppress glioblastoma U87 and U118 cell proliferation through the modulation of mitochondrial respiration and induce the downregulation of CHI3L1.宿主防御肽 1.1 和 1.9 通过调节线粒体呼吸抑制胶质母细胞瘤 U87 和 U118 细胞增殖，并诱导 CHI3L1 下调。
PLoS One. 2024 Jun 7;19(6):e0304149. doi: 10.1371/journal.pone.0304149. eCollection 2024.
4
LTF as a Potential Prognostic and Immunological Biomarker in Glioblastoma.LTF作为胶质母细胞瘤潜在的预后和免疫生物标志物
Biochem Genet. 2024 May 19. doi: 10.1007/s10528-024-10716-6.
5
A Pilot Cross-Sectional Study of Immunological and Microbiome Profiling Reveals Distinct Inflammatory Profiles for Smokers, Electronic Cigarette Users, and Never-Smokers.一项免疫和微生物组分析的试点横断面研究揭示了吸烟者、电子烟使用者和从不吸烟者不同的炎症特征。
Microorganisms. 2023 May 26;11(6):1405. doi: 10.3390/microorganisms11061405.
6
CHI3L1 induces autophagy through the JNK pathway in lung cancer cells.CHI3L1 通过 JNK 通路诱导肺癌细胞自噬。
Sci Rep. 2023 Jun 20;13(1):9964. doi: 10.1038/s41598-023-36844-4.
7
Sequential disruptions to inflammatory and angiogenic pathways and risk of spontaneous preterm birth in Malawian women.马拉维女性炎症和血管生成途径的连续性破坏与自发性早产风险
iScience. 2023 May 19;26(6):106912. doi: 10.1016/j.isci.2023.106912. eCollection 2023 Jun 16.
8
Ccr2+ Monocyte-Derived Macrophages Influence Trajectories of Acquired Therapy Resistance in Braf-Mutant Melanoma.CCR2+ 单核细胞衍生的巨噬细胞影响 BRAF 突变型黑色素瘤获得性治疗耐药的轨迹。
Cancer Res. 2023 Jul 14;83(14):2328-2344. doi: 10.1158/0008-5472.CAN-22-2841.
9
Compared to preoperative plasma levels post-operative urokinase-type plasminogen activator-1 levels are persistently elevated for 6 weeks after minimally invasive colorectal resection.与术前血浆水平相比，微创结直肠切除术后尿激酶型纤溶酶原激活物-1水平在6周内持续升高。
J Gastrointest Oncol. 2023 Feb 28;14(1):187-197. doi: 10.21037/jgo-22-113. Epub 2023 Feb 13.
10
Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status.蛋白质组学可将代谢亚群中的成人型弥漫性高级别神经胶质瘤与 1p/19q 缺失代码和 IDH 突变状态分开。
Cell Rep Med. 2023 Jan 17;4(1):100877. doi: 10.1016/j.xcrm.2022.100877. Epub 2022 Dec 29.
本文引用的文献
1
Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2.几丁质酶 3 样蛋白 1 通过白介素 13 受体 α2 调节细胞和组织反应。
Cell Rep. 2013 Aug 29;4(4):830-41. doi: 10.1016/j.celrep.2013.07.032. Epub 2013 Aug 22.
2
YKL-40 expression could be a poor prognostic marker in the breast cancer tissue.YKL-40表达可能是乳腺癌组织中一个预后不良的标志物。
Tumour Biol. 2014 Jan;35(1):277-86. doi: 10.1007/s13277-013-1036-0. Epub 2013 Aug 6.
3
YKL-40 induces IL-8 expression from bronchial epithelium via MAPK (JNK and ERK) and NF-κB pathways, causing bronchial smooth muscle proliferation and migration.YKL-40 通过 MAPK（JNK 和 ERK）和 NF-κB 途径诱导支气管上皮细胞表达 IL-8，导致支气管平滑肌增殖和迁移。
J Immunol. 2013 Jan 1;190(1):438-46. doi: 10.4049/jimmunol.1201827. Epub 2012 Nov 28.
4
Chitin microparticles for the control of intestinal inflammation.壳聚糖微球控制肠道炎症。
Inflamm Bowel Dis. 2012 Sep;18(9):1698-710. doi: 10.1002/ibd.22874. Epub 2012 Jan 12.
5
Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression.条件性敲除乳腺上皮细胞中的 Stat3 会损害泌乳后退化过程中的急性期反应并调节免疫细胞数量。
J Pathol. 2012 May;227(1):106-17. doi: 10.1002/path.3961. Epub 2012 Jan 27.
6
Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer.几丁质酶 3 样蛋白 1 促进结直肠癌中的巨噬细胞募集和血管生成。
Oncogene. 2012 Jun 28;31(26):3111-23. doi: 10.1038/onc.2011.498. Epub 2011 Nov 7.
7
Inhibitory activity of YKL-40 in mammary epithelial cell differentiation and polarization induced by lactogenic hormones: a role in mammary tissue involution.泌乳激素诱导的乳腺上皮细胞分化和极化中 YKL-40 的抑制活性：在乳腺组织退化中的作用。
PLoS One. 2011;6(10):e25819. doi: 10.1371/journal.pone.0025819. Epub 2011 Oct 3.
8
Breast cancer expression of YKL-40 correlates with tumour grade, poor differentiation, and other cancer markers.乳腺癌中 YKL-40 的表达与肿瘤分级、低分化和其他肿瘤标志物相关。
Br J Cancer. 2011 Oct 11;105(8):1203-9. doi: 10.1038/bjc.2011.347. Epub 2011 Sep 20.
9
Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD.肺特异性 IL-18 转基因小鼠、吸烟者和 COPD 患者中几丁质酶 3 样蛋白 1/YKL-40 的过度表达。
PLoS One. 2011;6(9):e24177. doi: 10.1371/journal.pone.0024177. Epub 2011 Sep 7.
10
Induction of proinflammatory mediators by CHI3L1 is reduced by chitin treatment: decreased tumor metastasis in a breast cancer model.几丁质处理可降低 CHI3L1 诱导的促炎介质：乳腺癌模型中肿瘤转移减少。
Int J Cancer. 2012 Jul 15;131(2):377-86. doi: 10.1002/ijc.26379. Epub 2011 Oct 20.
Zotero 插件