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CHI3L1 plays a role in cancer through enhanced production of pro-inflammatory/pro-tumorigenic and angiogenic factors.CHI3L1 通过增强促炎/促肿瘤发生和血管生成因子的产生在癌症中发挥作用。
Immunol Res. 2013 Dec;57(1-3):99-105. doi: 10.1007/s12026-013-8459-y.
2
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3
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YKL-40/CHI3L1 drives inflammation on the road of tumor progression.YKL-40/CHI3L1在肿瘤进展过程中引发炎症。
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本文引用的文献

1
Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2.几丁质酶 3 样蛋白 1 通过白介素 13 受体 α2 调节细胞和组织反应。
Cell Rep. 2013 Aug 29;4(4):830-41. doi: 10.1016/j.celrep.2013.07.032. Epub 2013 Aug 22.
2
YKL-40 expression could be a poor prognostic marker in the breast cancer tissue.YKL-40表达可能是乳腺癌组织中一个预后不良的标志物。
Tumour Biol. 2014 Jan;35(1):277-86. doi: 10.1007/s13277-013-1036-0. Epub 2013 Aug 6.
3
YKL-40 induces IL-8 expression from bronchial epithelium via MAPK (JNK and ERK) and NF-κB pathways, causing bronchial smooth muscle proliferation and migration.YKL-40 通过 MAPK（JNK 和 ERK）和 NF-κB 途径诱导支气管上皮细胞表达 IL-8，导致支气管平滑肌增殖和迁移。
J Immunol. 2013 Jan 1;190(1):438-46. doi: 10.4049/jimmunol.1201827. Epub 2012 Nov 28.
4
Chitin microparticles for the control of intestinal inflammation.壳聚糖微球控制肠道炎症。
Inflamm Bowel Dis. 2012 Sep;18(9):1698-710. doi: 10.1002/ibd.22874. Epub 2012 Jan 12.
5
Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression.条件性敲除乳腺上皮细胞中的 Stat3 会损害泌乳后退化过程中的急性期反应并调节免疫细胞数量。
J Pathol. 2012 May;227(1):106-17. doi: 10.1002/path.3961. Epub 2012 Jan 27.
6
Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer.几丁质酶 3 样蛋白 1 促进结直肠癌中的巨噬细胞募集和血管生成。
Oncogene. 2012 Jun 28;31(26):3111-23. doi: 10.1038/onc.2011.498. Epub 2011 Nov 7.
7
Inhibitory activity of YKL-40 in mammary epithelial cell differentiation and polarization induced by lactogenic hormones: a role in mammary tissue involution.泌乳激素诱导的乳腺上皮细胞分化和极化中 YKL-40 的抑制活性：在乳腺组织退化中的作用。
PLoS One. 2011;6(10):e25819. doi: 10.1371/journal.pone.0025819. Epub 2011 Oct 3.
8
Breast cancer expression of YKL-40 correlates with tumour grade, poor differentiation, and other cancer markers.乳腺癌中 YKL-40 的表达与肿瘤分级、低分化和其他肿瘤标志物相关。
Br J Cancer. 2011 Oct 11;105(8):1203-9. doi: 10.1038/bjc.2011.347. Epub 2011 Sep 20.
9
Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD.肺特异性 IL-18 转基因小鼠、吸烟者和 COPD 患者中几丁质酶 3 样蛋白 1/YKL-40 的过度表达。
PLoS One. 2011;6(9):e24177. doi: 10.1371/journal.pone.0024177. Epub 2011 Sep 7.
10
Induction of proinflammatory mediators by CHI3L1 is reduced by chitin treatment: decreased tumor metastasis in a breast cancer model.几丁质处理可降低 CHI3L1 诱导的促炎介质：乳腺癌模型中肿瘤转移减少。
Int J Cancer. 2012 Jul 15;131(2):377-86. doi: 10.1002/ijc.26379. Epub 2011 Oct 20.

CHI3L1 通过增强促炎/促肿瘤发生和血管生成因子的产生在癌症中发挥作用。

CHI3L1 plays a role in cancer through enhanced production of pro-inflammatory/pro-tumorigenic and angiogenic factors.

机构信息

Department of Biomedical Sciences, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.

出版信息

Immunol Res. 2013 Dec;57(1-3):99-105. doi: 10.1007/s12026-013-8459-y.

DOI:10.1007/s12026-013-8459-y
PMID:24222276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3966554/
Abstract

Elevated serum levels of a glycoprotein known as chitinase-3-like protein 1 (CHI3L1) have been correlated with poor prognosis and shorter survival of patients with cancer and inflammatory diseases. The biological and physiological functions of CHI3L1 in cancer have not yet been completely elucidated. In this review, we describe the role of CHI3L1 in inducing pro-inflammatory/pro-tumorigenic and angiogenic factors that could promote tumor growth and metastasis.

摘要

血清中一种名为壳三糖酶蛋白 3 样蛋白 1（CHI3L1）的糖蛋白水平升高与癌症和炎症性疾病患者的预后不良和生存期缩短相关。CHI3L1 在癌症中的生物学和生理学功能尚未完全阐明。在这篇综述中，我们描述了 CHI3L1 诱导促炎/促肿瘤发生和血管生成因子的作用，这些因子可促进肿瘤生长和转移。