通过“限制性蛋白酶”进行自我与非自我识别。
Self and non-self discrimination by "restriction proteases".
作者信息
Lefkovits I
出版信息
Proc Natl Acad Sci U S A. 1986 May;83(10):3437-8. doi: 10.1073/pnas.83.10.3437.
Abstract
I propose that an organism possesses a set of specific enzymes ("restriction proteases") that cleave self proteins at defined amino acid sequences unless these sequences are rendered inaccessible by glycosylation. Intracellular proteins are degraded by restriction proteases when cells die. In this way, intracellular proteins remain undetected by the immune system. I propose that some autoimmune diseases are caused by the absence of a specific restriction protease.
摘要
我提出，生物体拥有一组特定的酶（“限制性蛋白酶”），这些酶会在特定的氨基酸序列处切割自身蛋白质，除非这些序列因糖基化而无法接近。当细胞死亡时，细胞内的蛋白质会被限制性蛋白酶降解。通过这种方式，细胞内的蛋白质不会被免疫系统检测到。我提出，一些自身免疫性疾病是由特定限制性蛋白酶的缺失引起的。
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2
The Human Protein Index.
Clin Chem. 1982 Apr;28(4 Pt 2):739-48.
3
Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen.克隆无能：耐受小鼠体内存在对抗原或促有丝分裂原无反应的抗原结合B淋巴细胞。
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4
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J Cell Biol. 1983 Aug;97(2):293-300. doi: 10.1083/jcb.97.2.293.
5
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