Puciłowski O, Kozak W, Valzelli L
Pharmacol Biochem Behav. 1986 Mar;24(3):773-5. doi: 10.1016/0091-3057(86)90590-3.
Bilateral microinjections of 6-hydroxydopamine (6-OHDA) into the nuclei loci coerulei (LC) of male Wistar rats resulted in significant depletion of mesencephalic and striatal norepinephrine, accompanied by a small reduction in dopamine content only in the striatum. Apomorphine (2.5 mg/kg IP) induced marked aggression consisting of prolonged posturing, vocalization and attacks only in 6-OHDA lesioned animals. Biochemical analysis revealed that 6-OHDA antagonized the ability of apomorphine to raise the serotonin concentration in the striatum. It is concluded that the LC neurons play an inhibitory role in apomorphine-induced aggressiveness and the involvement of serotonergic neurons is suggested.
向雄性Wistar大鼠双侧黑质致密部（LC）微量注射6-羟基多巴胺（6-OHDA），导致中脑和纹状体去甲肾上腺素显著耗竭，仅纹状体中的多巴胺含量略有降低。阿扑吗啡（2.5mg/kg腹腔注射）仅在6-OHDA损伤的动物中诱导出明显的攻击行为，包括长时间的姿势、发声和攻击。生化分析表明，6-OHDA拮抗了阿扑吗啡提高纹状体中血清素浓度的能力。得出的结论是，LC神经元在阿扑吗啡诱导的攻击行为中起抑制作用，并提示血清素能神经元参与其中。
