Aytaç Erman, Teksöz Serkan, Saygılı Seha, Tortum Osman Baran, Yavuz Nihat, Sözer Volkan, Göksel Süha, Uzun Hafize, Seymen Hakkı Oktay, Göksoy Ertuğrul
İstanbul University Cerrahpaşa Medical Faculty, Department of General Surgery, İstanbul, Turkey.
Turk J Gastroenterol. 2013;24(3):224-9. doi: 10.4318/tjg.2013.0491.
BACKGROUND/AIMS: Reactive oxygen species have a known potent role in the pathogenesis of ulcerative colitis. Iloprost, a pharmaceutical, is a chemically stable derivative of a naturally- occurring human prostacyclin. Several studies have demonstrated protective effects of iloprost via its antioxidant and its anti-inflammatory activity. The aim of this study is to evaluate the effects of iloprost on oxidant/antioxidant status, as well as the large bowel histopathology in experimental colitis.
Forty adult male Wistar-albino rats were randomly divided in to four equal weight-matched groups: sham group (n=10), iloprost administered sham group (n=10), colitis group (n=10), iloprost administered colitis group (n=10). Acetic acid (1 ml of 4% solution) was used to induce colonic inflammation in the rats.
Colonic tissue and plasma malondialdehyde levels were significantly lower in the iloprost administered colitis group than the colitis group (p<0.01). Tissue glutathione levels of the iloprost administered colitis group were significantly higher than the colitis group (p<0.001).
We have demonstrated in this study iloprost to be an antioxidant, as well as iloprost demonstrating protective activity against colitis induced oxidative stress.
背景/目的：活性氧在溃疡性结肠炎的发病机制中具有重要作用。伊洛前列素是一种药物，是天然存在的人类前列环素的化学稳定衍生物。多项研究表明，伊洛前列素通过其抗氧化和抗炎活性发挥保护作用。本研究旨在评估伊洛前列素对实验性结肠炎中氧化/抗氧化状态以及大肠组织病理学的影响。
40只成年雄性Wistar白化大鼠随机分为四个体重匹配的相等组：假手术组（n = 10）、给予伊洛前列素的假手术组（n = 10）、结肠炎组（n = 10）、给予伊洛前列素的结肠炎组（n = 10）。用乙酸（1毫升4%溶液）诱导大鼠结肠炎症。
给予伊洛前列素的结肠炎组结肠组织和血浆丙二醛水平显著低于结肠炎组（p < 0.01）。给予伊洛前列素的结肠炎组组织谷胱甘肽水平显著高于结肠炎组（p < 0.001）。
我们在本研究中证明伊洛前列素是一种抗氧化剂，并且伊洛前列素对结肠炎诱导的氧化应激具有保护活性。
