Aprotinin does not add protective effect to cold cardioplegia during coronary artery bypass surgery.

The effect of aprotinin on intraoperative and postoperative CK-MB and left ventricular contractility in terms of dp/dt response to atrial pacing up to 150 beats/min was studied in 20 patients randomized before aortocoronary bypass surgery to either aprotinin or placebo administration. Cold cardioplegia and topical deep hypothermia were used in both groups. No difference could be demonstrated between the aprotinin and the placebo group, and the authors therefore concluded that aprotinin does not add substantially to the protective effect of cold cardioplegia and deep topical hypothermia during aortocoronary bypass surgery.