在低亲和力肝素或硫酸葡聚糖存在的情况下，氯化钠对抗凝血酶III灭活牛凝血酶的影响。

Effect of NaC1 on inactivation of bovine thrombin by antithrombin III in the presence of low affinity-heparin or dextran sulfate.

作者信息

Oshima G, Nagasawa K

出版信息

Thromb Res. 1986 Feb 1;41(3):361-72. doi: 10.1016/0049-3848(86)90247-1.

Abstract

Heparin with low affinity (LA-heparin) to antithrombin III (AT III) enhanced the rate of inactivation of thrombin by AT III. The enhancement of the rate was saturable with AT III and was proportional to the LA-heparin concentration. Although the rate-enhancement in the presence of LA-heparin decreased with increase in NaC1 concentration, it was comparable with that in the presence of high affinity-heparin (HA-heparin) in the absence of NaC1. Inactivation of thrombin by AT III in the presence of dextran sulfate (DS) was also sensitive to NaC1 concentration. These findings indicate that free AT III is favorable for binding to the complexes of thrombin and highly sulfated polysaccharides having low affinities to AT III in the absence of NaC1.

摘要

与抗凝血酶III（AT III）具有低亲和力的肝素（低亲和力肝素，LA - 肝素）提高了AT III使凝血酶失活的速率。该速率的提高对AT III具有饱和性，且与LA - 肝素浓度成正比。尽管在存在LA - 肝素的情况下速率提高会随着氯化钠浓度的增加而降低，但在无氯化钠时它与存在高亲和力肝素（HA - 肝素）时相当。在存在硫酸葡聚糖（DS）的情况下，AT III使凝血酶失活也对氯化钠浓度敏感。这些发现表明，在无氯化钠时，游离的AT III有利于与凝血酶和对AT III具有低亲和力的高度硫酸化多糖的复合物结合。