后马托品滴眼液对屈光性角膜切削术后疼痛的影响：一项初步研究。
Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study.
作者信息
Joshaghani Mahmoud, Nazari Hossein, Ghasemi Falavarjani Khalil, Shokrollahi Siamak, Jafar Ghaempanah Mohammad, Abri Aghdam Kaveh, Mirbolouk Jalali Zahra
机构信息
Eye Research Center and Eye Department, Rassoul Akram Hospital, Sattarkhan-Niaiesh St., Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Saudi J Ophthalmol. 2013 Apr;27(2):83-5. doi: 10.1016/j.sjopt.2012.07.003. Epub 2012 Jul 31.
PURPOSE
To assess the effect of homatropine eye drops on pain after photorefractive keratectomy (PRK).
METHODS
This randomized, double masked, interventional study included 15 patients (30 eyes) who underwent bilateral PRK. After operation, patients received homatropine eye drops, 4 times daily in only one eye (homatropine eye). The level of pain was evaluated using visual analogue scale (VAS), verbal rating scale (VRS) and pain rating index (PRI) at 0.5, 24 and 48 h after operation.
RESULTS
The level of pain was statistically similar between the two eyes half an hour after operation, however, homatropine eyes had significantly less pain 24 h after operation compared to fellow eyes (2.5 ± 1.9 vs 5.3 ± 2.5, P = 0.004 for VAS, 2.0 ± 1.2 vs 3.2 ± 0.9, P = 0.023 for VRS, and 9.4 ± 5.7 vs 16.0 ± 9.0, P = 0.031 for PRI). Also, 48 h after surgery, the pain scales were less in the homatropine eyes (2.3 ± 1.7 vs 4.0 ± 2.1, P = 0.014 for VAS, 1.6 ± 1.0 vs 2.5 ± 1.0, P = 0.038 for VRS, and 6.8 ± 5.7 vs 12.0 ± 8.9, P = 0.005 for PRI). No delayed epithelial healing was observed.
CONCLUSION
Homatropine eye drops may be useful for reducing pain after Photorefractive keratectomy.
目的
评估后马托品滴眼液对准分子激光角膜切削术（PRK）后疼痛的影响。
方法
这项随机、双盲、干预性研究纳入了15例接受双侧PRK的患者（30只眼）。术后，患者仅在一只眼（后马托品眼）每日4次滴用后马托品滴眼液。术后0.5、24和48小时使用视觉模拟量表（VAS）、言语评定量表（VRS）和疼痛评定指数（PRI）评估疼痛程度。
结果
术后半小时，两只眼的疼痛程度在统计学上相似，然而，与对侧眼相比，后马托品眼术后24小时疼痛明显减轻（VAS：2.5±1.9对5.3±2.5，P = 0.004；VRS：2.0±1.2对3.2±0.9，P = 0.023；PRI：9.4±5.7对16.0±9.0，P = 0.031）。此外，术后48小时，后马托品眼的疼痛量表评分更低（VAS：2.3±1.7对4.0±2.1，P = 0.014；VRS：1.6±1.0对2.5±1.0，P = 0.038；PRI：6.8±5.7对12.0±8.9，P = 0.005）。未观察到上皮延迟愈合。
结论
后马托品滴眼液可能有助于减轻准分子激光角膜切削术后的疼痛。
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