Vergadoro F, Tabacchi L, Barbacini P, Vassena L, Zanaboni F, Bolis G
Tumori. 1986 Apr 30;72(2):205-9. doi: 10.1177/030089168607200216.
Thyroid function was assessed in a total of 15 cases, 7 of whom had choriocarcinoma and 8 hydatidiform mole, by measuring free T3, free T4, thyroxin-binding globulin (TBG), basal thyroid-stimulating hormone (TSH) and after the thyrotropin-releasing hormone test (delta TSH). Free T3, free T4 and TBG were investigated in the same number of healthy women within the first three months of pregnancy. Only 13.4% of the cases presented elevated levels of free T3 and T4 and TBG; TSH and delta TSH were within normal limits. Both thyroid hormones and TBG returned to within normal limits when beta-human chorionic gonadotropin became undetectable. One patient was found to be hypothyroid. Comparison with the control group showed no significant differences except in TBG levels, which were higher in controls. A significant, direct correlation was found between levels of free T3 and T4 and TBG and the pattern of human chorionic gonadotropin.
通过测量游离T3、游离T4、甲状腺素结合球蛋白（TBG）、基础促甲状腺激素（TSH）以及促甲状腺激素释放激素试验后（△TSH），对总共15例患者的甲状腺功能进行了评估，其中7例为绒毛膜癌，8例为葡萄胎。对相同数量的妊娠前三个月内的健康女性进行了游离T3、游离T4和TBG的检测。仅13.4%的病例出现游离T3、T4和TBG水平升高；TSH和△TSH在正常范围内。当β-人绒毛膜促性腺激素检测不到时，甲状腺激素和TBG均恢复到正常范围内。发现1例患者甲状腺功能减退。与对照组比较，除TBG水平外无显著差异，对照组的TBG水平更高。游离T3、T4和TBG水平与人绒毛膜促性腺激素的模式之间存在显著的直接相关性。
