Chen Zhong-Yan, Yao Wei-Juan
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Sheng Li Ke Xue Jin Zhan. 2013 Aug;44(4):269-74.
The migration of vascular smooth muscle cells (VSMCs) from media to intima is a critical step in the formation of atheroma and vascular stenosis as well as in the restenosis after vascular intervention. As an important downstream effector of RhoA, Rho-associated kinase (ROCK) plays an important role in VSMC migration and vascular remodeling by regulating actin filament cytoskeleton and focal adhesion. There are many bioactive substances such as aldosterone, sphingosine 1 phosphate (S1P), platelet-derived growth factor (PDGF) and angiotensin II (Ang II) that could induce VSMC migration through Rho/ROCK pathway by binding to their specific receptors. Studies on Rho/ROCK pathway could help us to better understand how cardiovascular diseases such as atherosclerosis and hypertension develop.
血管平滑肌细胞（VSMCs）从血管中膜迁移至内膜是动脉粥样硬化、血管狭窄形成以及血管介入后再狭窄过程中的关键步骤。作为RhoA的重要下游效应器，Rho相关激酶（ROCK）通过调节肌动蛋白丝细胞骨架和黏着斑，在VSMC迁移和血管重塑中发挥重要作用。有许多生物活性物质，如醛固酮、1-磷酸鞘氨醇（S1P）、血小板衍生生长因子（PDGF）和血管紧张素II（Ang II），它们可通过与特定受体结合，经Rho/ROCK途径诱导VSMC迁移。对Rho/ROCK途径的研究有助于我们更好地理解动脉粥样硬化和高血压等心血管疾病的发病机制。
