Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072, China.
Org Lett. 2013 Dec 20;15(24):6222-5. doi: 10.1021/ol4030716. Epub 2013 Nov 14.
A variety of enaminones and enamine carboxylic esters were converted to trifluoroethoxylated 2H-azirines through reactions with PhIO in trifluoroethanol (TFE). The cascade reaction is postulated to proceed via a PhIO-mediated oxidative trifluoroethoxylation and a subsequent azirination of the α-trifluoroethoxylated enamine intermediates.
各种烯胺酮和烯胺羧酸酯通过与三氟乙醇（TFE）中的间氯过氧苯甲酸（PhIO）反应转化为三氟乙氧基化 2H-氮丙啶。推测该级联反应是通过 PhIO 介导的氧化三氟乙氧基化和随后的α-三氟乙氧基化烯胺中间体的氮丙啶化反应进行的。
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