通过PhIO介导的脱氢反应构建带有吸电子基团的三取代色酮骨架及其在弗鲁蒂诺酮A合成中的应用。

Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A.

作者信息

Li Qiao, Zhuang Chen, Wang Donghua, Zhang Wei, Jia Rongxuan, Sun Fengxia, Zhang Yilin, Du Yunfei

机构信息

Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.

College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology; Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, China.

出版信息

Beilstein J Org Chem. 2019 Dec 12;15:2958-2965. doi: 10.3762/bjoc.15.291. eCollection 2019.

The construction of the biologically interesting chromone skeleton was realized by PhIO-mediated dehydrogenation of chromanones under mild conditions. Interestingly, this method also found application in the synthesis of the naturally occurring frutinone A.