Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
Chin Med J (Engl). 2013 Nov;126(21):4175-82.
To summarize the recent findings of dysregulation of signaling pathways and miRNAs in chronic lymphocytic leukemia (CLL).
We searched PubMed database with the keywords "chronic lymphocytic leukemia", "signal pathway", or "miRNA" for relevant articles in recent years.
Research articles and reviews about signaling pathways and miRNAs in CLL were chosen for review.
Dysregulation of signaling pathways, such as B cell receptor , toll-like receptor, PI3K, nuclear factor κB, notch signaling pathway, Wnt/Fzd signaling pathway, and Hedgehog and Janus kinases/signal transducers and activators of transcription signaling pathway, as the terminal events of the aberrant gene expression and the pro-survival effects of microenvironment, plays a crucial role in the process of CLL. miRNAs, a novel found noncoding RNA, which regulate gene expression at transcription or post-transcription level and correlate with pathogenesis of CLL provide us new avenues to better evaluating prognosis and therapy of it.
Further investigation of the dysregulation of signaling pathways and miRNAs and their relationship may provide us a new prospective to understand the pathogenesis of CLL and may provide us new strategies to resolve the clinical nodi in treatment of CLL.
总结慢性淋巴细胞白血病（CLL）中信号通路和 miRNA 失调的最新研究结果。
我们使用“慢性淋巴细胞白血病”、“信号通路”或“miRNA”等关键词在 PubMed 数据库中搜索了近年来的相关文章。
选择了关于 CLL 中信号通路和 miRNA 的研究文章和综述进行综述。
信号通路的失调，如 B 细胞受体、Toll 样受体、PI3K、核因子 κB、Notch 信号通路、Wnt/Fzd 信号通路和 Hedgehog 和 Janus 激酶/信号转导和转录激活因子信号通路，作为异常基因表达的终末事件和微环境的生存促进作用，在 CLL 过程中发挥着至关重要的作用。miRNA 是一种新发现的非编码 RNA，可在转录或转录后水平调节基因表达，并与 CLL 的发病机制相关，为我们提供了更好地评估其预后和治疗的新途径。
进一步研究信号通路和 miRNA 的失调及其关系，可能为我们深入了解 CLL 的发病机制提供新的视角，并为解决 CLL 治疗中的临床难题提供新的策略。
