University Hospital Rostock, Rostock, Germany; Cardiovascular Center Darmstadt, Darmstadt, Germany.
JACC Cardiovasc Imaging. 2013 Nov;6(11):1191-205. doi: 10.1016/j.jcmg.2013.07.008.
Although the prevalence of rheumatic fever is decreasing in developed countries, it still affects numerous areas in the nonindustrialized world. Untreated mitral stenosis (MS) contributes to a significant global morbidity and mortality. Echocardiography is the main diagnostic imaging modality with which to evaluate mitral valve (MV) obstruction and assess the severity and hemodynamic consequences of MS as well as valve morphology. According to current guidelines and recommendations for clinical practice, the severity of MS should not be defined by a single value but assessed by valve areas, mean Doppler gradients, and pulmonary pressures. Transthoracic echocardiography is usually sufficient to grade MS severity and to define the morphology of the valve. Transesophageal echocardiography is used when the valve cannot be adequately assessed with transthoracic echocardiography and to exclude intracardiac thrombi before a percutaneous or surgical intervention. Three-dimensional transthoracic and transesophageal echocardiographic assessment provide more detailed physiological and morphological information. Current definitive treatment for severe MS involves percutaneous mitral balloon valvuloplasty (PMBV) or surgery. The effectiveness of PMBV is related to the etiology of MS, and certain anatomic characteristics tend to predict a more successful outcome for PMBV, whereas other MV structural findings might suggest balloon valvuloplasty to be less likely successful or even contraindicated.
尽管风湿热在发达国家的发病率正在下降,但它仍然影响着非工业化世界的许多地区。未经治疗的二尖瓣狭窄(MS)会导致严重的全球发病率和死亡率。超声心动图是评估二尖瓣(MV)阻塞、评估 MS 的严重程度和血流动力学后果以及瓣膜形态的主要诊断成像方式。根据目前的临床实践指南和建议,MS 的严重程度不应仅由单一数值定义,而应通过瓣口面积、平均多普勒梯度和肺动脉压来评估。经胸超声心动图通常足以评估 MS 的严重程度并确定瓣膜的形态。当经胸超声心动图不能充分评估瓣膜时,以及在经皮或手术干预前排除心内血栓时,使用经食管超声心动图。三维经胸和经食管超声心动图评估可提供更详细的生理和形态信息。目前,严重 MS 的确定性治疗包括经皮二尖瓣球囊成形术(PMBV)或手术。PMBV 的有效性与 MS 的病因有关,某些解剖特征往往预示着 PMBV 的结果更成功,而其他 MV 结构发现可能表明球囊成形术不太可能成功,甚至是禁忌。