García Alberto, Martínez Miguel A, Peña Estefanía
J Biomech Eng. 2013 Mar 1;135(3):31004. doi: 10.1115/1.4023371.
The study of the mechanical properties of swine carotids has clinical relevance because it is important for the appropriate design of intravascular devices in the animal trial phases. The inelastic properties of porcine carotid tissue were investigated. Experimental uniaxial cyclic tests were performed along the longitudinal and circumferential directions of vessels. The work focused on the determination, comparison, and constitutive modeling of the softening properties and residual stretch set of the swine carotid artery over long stretches and stress levels in both proximal and distal regions. It was observed that the residual strain depends on the maximum stretch in the previous load cycle. The strain was higher for distal than for proximal samples and for circumferential than for longitudinal samples. In addition, a pseudoelastic model was used to reproduce the residual stretch and softening behavior of the carotid artery. The model presented a good approximation of the experimental data. The results demonstrate that the final results in animal trial studies could be affected by the location studied along the length of the porcine carotid.
对猪颈动脉力学特性的研究具有临床相关性，因为这对于动物试验阶段血管内装置的合理设计很重要。研究了猪颈动脉组织的非弹性特性。沿血管的纵向和周向进行了实验性单轴循环测试。这项工作重点在于确定、比较猪颈动脉在近端和远端区域的长拉伸和应力水平下的软化特性及残余拉伸应变，并进行本构建模。观察到残余应变取决于前一加载循环中的最大拉伸。远端样本的应变高于近端样本，周向样本的应变高于纵向样本。此外，使用了一个伪弹性模型来再现颈动脉的残余拉伸和软化行为。该模型对实验数据给出了良好的近似。结果表明，动物试验研究的最终结果可能会受到沿猪颈动脉长度所研究位置的影响。
