Department of Pediatrics, College of Medicine, Korea University, Seoul, South Korea.
Pediatr Res. 2014 Feb;75(2):259-65. doi: 10.1038/pr.2013.223. Epub 2013 Nov 14.
We evaluated the influence of postnatal early overnutrition on renal pathophysiological changes in aging rats.
Three or 10 male pups per mother were assigned to either the small litter (SL) or normal litter (control) groups, respectively, during the first 21 d of life. The effects of early postnatal overnutrition were determined at 12 mo.
SL rats weighed more than controls between 4 d and 6 mo of age (P < 0.05). However, between 6 and 12 mo, body weights in both groups were not different. In the SL group, at 12 mo, systolic blood pressure was higher and creatinine clearance was lower than the same in controls (P < 0.05). Numbers of CD68 (ED1)-positive macrophages and apoptotic cells in renal cortex were higher in SL rats (P < 0.05). Furthermore, index scores for glomerulosclerosis and tubulointerstitial fibrosis were higher in the SL group (P < 0.05). Significantly less glomeruli per section area were found in aging SL rats (P < 0.05). Immunoblotting and immunohistochemistry showed decreased intrarenal renin expression in SL rats (P < 0.05).
Early postnatal overnutrition can potentiate structural and functional abnormalities in the aging kidney and can lead to systolic hypertension with reduced intrarenal renin activity.
我们评估了产后早期营养过剩对老年大鼠肾脏病理生理变化的影响。
在生命的头 21 天内，每只母鼠分别将 3 或 10 只雄性幼崽分配到小窝（SL）或正常窝（对照组）中。在 12 个月时确定早期产后营养过剩的影响。
SL 组大鼠在 4 至 6 月龄时体重超过对照组（P < 0.05）。然而，在 6 至 12 个月之间，两组的体重没有差异。在 SL 组，12 个月时收缩压升高，肌酐清除率低于对照组（P < 0.05）。SL 大鼠肾皮质中 CD68（ED1）阳性巨噬细胞和凋亡细胞的数量更高（P < 0.05）。此外，SL 组肾小球硬化和肾小管间质纤维化的指标评分更高（P < 0.05）。老化的 SL 大鼠每部分面积的肾小球数量明显减少（P < 0.05）。免疫印迹和免疫组织化学显示 SL 大鼠肾内肾素表达减少（P < 0.05）。
产后早期营养过剩可加剧老年肾脏的结构和功能异常，并导致收缩压升高和肾内肾素活性降低。
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