Mol Biol Rep. 2014 Jan;41(1):317-24. doi: 10.1007/s11033-013-2864-0.
Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease. Single nucleotide polymorphisms of tumor necrosis factor-receptor associated factor 1/complement component 5 (TRAF1/C5) gene are suspected to be associated with the risk of RA. This meta-analysis was performed to study the relationship between the polymorphism rs10818488 in TRAF1/C5 gene with RA. We retrieved the relevant articles from PubMed, EMBASE and the China National Knowledge Infrastructure databases. Odd ratios were calculated to assess the association between TRAF1/C5 rs10818488 polymorphism and RA risk. Meta-analyses were performed on the total data set and separately for the major ethnic groups and RF and ACAP status. All analyses were performed using the Stata software. Eight articles were included in the present analysis. Meta-analysis showed a weak association between TRAF1/C5 rs10818488 polymorphism and RA in all subjects (OR = 1.13, 95 % CI = 1.01–1.27, P heterogeneity < 0.001). Stratified analyses indicated that the TRAF1/C5 rs10818488 A allele was significantly associated with RA in Caucasians (OR = 1.29, 95 %CI = 1.14–1.47, P heterogeneity = 0.026), Asians (OR = 0.92, 95 %CI = 0.86–0.99, P heterogeneity = 0.378) and Africans (OR = 1.56, 95 %CI = 1.23–1.98, P heterogeneity = 0.876), also significantly in positive ACPA and positive RF patients versus controls (ORs were 1.20 and 1.25, 95 %CIs were 1.08–1.33 and 1.14–1.37, P values for heterogeneity were 0.215 and 0.133, respectively). Genetic polymorphism rs10818488 in TRAF1/C5 gene might be associated with RA susceptibility.
类风湿关节炎（RA）是一种常见的慢性炎症性自身免疫性疾病。肿瘤坏死因子受体相关因子 1/补体成分 5（TRAF1/C5）基因的单核苷酸多态性被怀疑与 RA 的风险有关。本荟萃分析旨在研究 TRAF1/C5 基因中 rs10818488 多态性与 RA 之间的关系。我们从 PubMed、EMBASE 和中国国家知识基础设施数据库中检索到相关文章。使用比值比来评估 TRAF1/C5 rs10818488 多态性与 RA 风险之间的关系。对总数据集以及主要种族群体和 RF 和 ACAP 状态进行了荟萃分析。所有分析均使用 Stata 软件进行。本分析共纳入 8 篇文章。荟萃分析显示，TRAF1/C5 rs10818488 多态性与所有受试者的 RA 之间存在弱关联（OR=1.13，95%CI=1.01-1.27，P 异质性<0.001）。分层分析表明，TRAF1/C5 rs10818488A 等位基因与高加索人（OR=1.29，95%CI=1.14-1.47，P 异质性=0.026）、亚洲人（OR=0.92，95%CI=0.86-0.99，P 异质性=0.378）和非洲人（OR=1.56，95%CI=1.23-1.98，P 异质性=0.876）的 RA 显著相关，在 ACPA 阳性和 RF 阳性患者与对照组相比也显著相关（OR 分别为 1.20 和 1.25，95%CI 分别为 1.08-1.33 和 1.14-1.37，P 值异质性分别为 0.215 和 0.133）。TRAF1/C5 基因中的遗传多态性 rs10818488 可能与 RA 的易感性有关。
