Rao Radhakrishna K
Department of Physiology (RKO), University of Tennessee Health Science Center, Memphis, Tennessee.
Alcohol Clin Exp Res. 2014 Feb;38(2):309-11. doi: 10.1111/acer.12295. Epub 2013 Nov 15.
Elamin and colleagues in this issue report that acetaldehyde activates Snail, a transcription factor involved in epithelial-to-mesenchymal transition, in an intestinal epithelium. Snail mediates acetaldehyde-induced tight junction disruption and increase in paracellular permeability. Results of this study and other previous studies raise several important questions. This commentary addresses these questions by discussing the acetaldehyde concentration in colon, disruption of epical junctional complexes in the intestinal epithelium by acetaldehyde, and the consequence of long-term exposure to acetaldehyde on colonic epithelial regeneration, carcinogenesis, and metastases. The precise role of acetaldehyde in colonic epithelial modifications and promotion of colorectal cancers still remains to be understood.
伊拉明及其同事在本期报道称，乙醛可激活肠道上皮中的蜗牛蛋白（一种参与上皮-间质转化的转录因子）。蜗牛蛋白介导乙醛诱导的紧密连接破坏和细胞旁通透性增加。这项研究及其他先前研究的结果提出了几个重要问题。本述评通过讨论结肠中的乙醛浓度、乙醛对肠道上皮顶端连接复合体的破坏以及长期接触乙醛对结肠上皮再生、致癌作用和转移的影响来探讨这些问题。乙醛在结肠上皮修饰和促进结直肠癌中的精确作用仍有待了解。
